Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Research Project (R01)
Project #
1R01AR043356-01A2
Application #
2006438
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1997-01-01
Project End
1997-06-30
Budget Start
1997-01-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Yale University
Department
Dermatology
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Carter, Eric L; O'Herrin, Sean; Woolery, Carla et al. (2008) Epidermal stem cell factor augments the inflammatory response in irritant and allergic contact dermatitis. J Invest Dermatol 128:1861-3
Yang, Bing; O'Herrin, Sean M; Wu, Jianqiang et al. (2007) MAGE-A, mMage-b, and MAGE-C proteins form complexes with KAP1 and suppress p53-dependent apoptosis in MAGE-positive cell lines. Cancer Res 67:9954-62
Yang, Bing; Wu, Jianqiang; Maddodi, Nityanand et al. (2007) Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. J Invest Dermatol 127:2123-8
Yang, Bing; O'Herrin, Sean; Wu, Jianqiang et al. (2007) Select cancer testes antigens of the MAGE-A, -B, and -C families are expressed in mast cell lines and promote cell viability in vitro and in vivo. J Invest Dermatol 127:267-75
Hartmann, Karin; Wardelmann, Eva; Ma, Yongsheng et al. (2005) Novel germline mutation of KIT associated with familial gastrointestinal stromal tumors and mastocytosis. Gastroenterology 129:1042-6
Ma, Yongsheng; Zeng, Shan; Metcalfe, Dean D et al. (2002) The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations. Blood 99:1741-4
Ma, Y; Carter, E; Wang, X et al. (2000) Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol 114:392-4
Longley, B J; Ma, Y; Carter, E et al. (2000) New approaches to therapy for mastocytosis. A case for treatment with kit kinase inhibitors. Hematol Oncol Clin North Am 14:689-95
Longley, B J; Metcalfe, D D (2000) A proposed classification of mastocytosis incorporating molecular genetics. Hematol Oncol Clin North Am 14:697-701, viii
Ma, Y; Longley, B J; Wang, X et al. (1999) Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms. J Invest Dermatol 112:165-70

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