The aims of this proposal are multifaceted. One area of activity will be devoted to probing possible relationships between di-, tri-, and tetraepoxides of unusual structure and tumor-inhibitory activity. This effort will require the development of innovative approaches to new polycyclic polyolefins. Also to be prepared are new optically active ferrocenes and ferrocenium salts, the goal being to gain improved appreciation of the antineoplastic potential of this class of compounds and to develop them into useful new tools for asymmetric synthesis. Because ingenol esters exhibit pronounced cocarcinogenic or antileukemic properties, a number of members of this group and their structural analogues (particularly the 8-epi series) have been targeted for total synthesis. Dolatriol and several related diterpenes of marine origin, compounds that exhibit impressive cytotoxic activity, also have been affirmed as synthetic objectives. In yet a very different arena, synthetic approaches to a number of furanocembranolides, recognized for their potent biological effects, will be undertaken.

National Institute of Health (NIH)
National Cancer Institute (NCI)
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Bio-Organic and Natural Products Chemistry Study Section (BNP)
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Ohio State University
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Carter, Yvette M; Kunnimalaiyaan, Selvi; Chen, Herbert et al. (2014) Specific glycogen synthase kinase-3 inhibition reduces neuroendocrine markers and suppresses neuroblastoma cell growth. Cancer Biol Ther 15:510-5
Carter, Yvette; Chen, Herbert; Sippel, Rebecca S (2014) An intact parathyroid hormone-based protocol for the prevention and treatment of symptomatic hypocalcemia after thyroidectomy. J Surg Res 186:23-8
Carter, Yvette; Yeutter, Nicholas; Mazeh, Haggi (2014) Thyroglossal duct remnant carcinoma: beyond the Sistrunk procedure. Surg Oncol 23:161-6
Carter, Yvette; Sippel, Rebecca S; Chen, Herbert (2014) Hypothyroidism after a cancer diagnosis: etiology, diagnosis, complications, and management. Oncologist 19:34-43
Alhefdhi, Amal; Burke, Jocelyn F; Redlich, Aaron et al. (2013) Leflunomide suppresses growth in human medullary thyroid cancer cells. J Surg Res 185:212-6
Carter, Yvette; Roy, Madhuchhanda; Sippel, Rebecca S et al. (2012) Persistent hypertension after adrenalectomy for an aldosterone-producing adenoma: weight as a critical prognostic factor for aldosterone's lasting effect on the cardiac and vascular systems. J Surg Res 177:241-7
Xiao, Yuling; Jaskula-Sztul, Renata; Javadi, Alireza et al. (2012) Co-delivery of doxorubicin and siRNA using octreotide-conjugated gold nanorods for targeted neuroendocrine cancer therapy. Nanoscale 4:7185-93
Carter, Yvette M; Mazeh, Haggi; Sippel, Rebecca S et al. (2012) Safety and feasibility of laparoscopic resection for large (ýýý 6 CM) pheochromocytomas without suspected malignancy. Endocr Pract 18:720-6
Hou, Ningqi; Popkin, Barry M; Jacobs Jr, David R et al. (2011) Longitudinal trends in gasoline price and physical activity: the CARDIA study. Prev Med 52:365-9
Hou, Ningqi; Popkin, Barry M; Jacobs Jr, David R et al. (2010) Longitudinal associations between neighborhood-level street network with walking, bicycling, and jogging: the CARDIA study. Health Place 16:1206-15

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