Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA017395-11
Application #
4690700
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Li, Haoquan; Endutkin, Anton V; Bergonzo, Christina et al. (2017) DNA Deformation-Coupled Recognition of 8-Oxoguanine: Conformational Kinetic Gating in Human DNA Glycosylase. J Am Chem Soc 139:2682-2692
Li, Haoquan; Endutkin, Anton V; Bergonzo, Christina et al. (2016) A dynamic checkpoint in oxidative lesion discrimination by formamidopyrimidine-DNA glycosylase. Nucleic Acids Res 44:683-94
Gao, Shujuan; Honey, Sangeet; Futcher, Bruce et al. (2016) The non-homologous end-joining pathway of S. cerevisiae works effectively in G1-phase cells, and religates cognate ends correctly and non-randomly. DNA Repair (Amst) 42:1-10
Kuznetsov, Nikita A; Bergonzo, Christina; Campbell, Arthur J et al. (2015) Active destabilization of base pairs by a DNA glycosylase wedge initiates damage recognition. Nucleic Acids Res 43:272-81
Lukina, Maria V; Popov, Alexander V; Koval, Vladimir V et al. (2013) DNA damage processing by human 8-oxoguanine-DNA glycosylase mutants with the occluded active site. J Biol Chem 288:28936-47
Kuznetsov, Nikita A; Koval, Vladimir V; Zharkov, Dmitry O et al. (2012) Conformational dynamics of the interaction of Escherichia coli endonuclease VIII with DNA substrates. DNA Repair (Amst) 11:884-91
Bergonzo, Christina; Campbell, Arthur J; de los Santos, Carlos et al. (2011) Energetic preference of 8-oxoG eversion pathways in a DNA glycosylase. J Am Chem Soc 133:14504-6
Kirpota, Oleg O; Endutkin, Anton V; Ponomarenko, Michail P et al. (2011) Thermodynamic and kinetic basis for recognition and repair of 8-oxoguanine in DNA by human 8-oxoguanine-DNA glycosylase. Nucleic Acids Res 39:4836-50
Mechetin, Grigory V; Zharkov, Dmitry O (2011) Mechanism of translocation of uracil-DNA glycosylase from Escherichia coli between distributed lesions. Biochem Biophys Res Commun 414:425-30
Zharkov, Dmitry O; Mechetin, Grigory V; Nevinsky, Georgy A (2010) Uracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognition. Mutat Res 685:11-20

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