Abstract

Three basic lines of investigation pertaining to the control of erythroid differentiation of murine erythroleukemia cells will be investigated. The molecular processes that are responsible for the commitment of these cells to terminal erythroid differentiation will be studied. The relationship between globin mRNA synthesis and commitment will be analyzed. The control of genes expressed during the terminal phase of the program will also be studied. (M)

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA017575-11
Application #
3164735
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1978-05-01
Project End
1988-04-30
Budget Start
1985-05-01
Budget End
1986-04-30
Support Year
11
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code

  Publications

Sobulo, O M; Borrow, J; Tomek, R et al. (1997) MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proc Natl Acad Sci U S A 94:8732-7
Flores, J F; Walker, G J; Glendening, J M et al. (1996) Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res 56:5023-32
Aburatani, H; Stanton Jr, V P; Housman, D E (1996) High-resolution physical mapping by combined Alu-hybridization/PCR screening: construction of a yeast artificial chromosome map covering 31 centimorgans in 3p21-p14. Proc Natl Acad Sci U S A 93:4474-9
Borrow, J; Shearman, A M; Stanton Jr, V P et al. (1996) The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet 12:159-67
Lowe, S W; Jacks, T; Housman, D E et al. (1994) Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A 91:2026-30
Lowe, S W; Bodis, S; McClatchey, A et al. (1994) p53 status and the efficacy of cancer therapy in vivo. Science 266:807-10
Coleman, A; Fountain, J W; Nobori, T et al. (1994) Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia. Cancer Res 54:344-8
Lowe, S W; Bodis, S; Bardeesy, N et al. (1994) Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harb Symp Quant Biol 59:419-26
Petty, E M; Gibson, L H; Fountain, J W et al. (1993) Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s). Am J Hum Genet 53:96-104
Lowe, S W; Ruley, H E; Jacks, T et al. (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957-67

Showing the most recent 10 out of 37 publications