Research on the isolation and structure determination of biologically active natural products is proposed. The major emphasis will be on precisely defining the three-dimensional molecular structures of polyether macrolides, antitumor antibiotics, and heteropeptides by single crystal X-ray diffraction techniques. Specific projects described in the proposal include: 1. Compounds related to scytophycin such as tolytoxin, swinholide A, kabiramide, ulapualide, and halichondramide. 2. Antitumor antitiotics in the esperamicin and neocarzinostatin families. 3. Heteropeptides such as the theonellapeptolides, PD 124966, ulicyclamides, and didemnins. The molecular structure information obtained from this research will be of direct benefit to chemistry, biochemistry, and pharmacology. Several of the research targets could become useful drugs for the treatment of human diseases. The esperamicin antitumor antibiotics are especially promising as chemotherapeutic agents.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA024487-11
Application #
3166465
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1979-02-01
Project End
1993-01-31
Budget Start
1989-02-01
Budget End
1990-01-31
Support Year
11
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Cornell University
Department
Type
Schools of Arts and Sciences
DUNS #
City
Ithaca
State
NY
Country
United States
Zip Code
14850
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