The conventional LPS or endotoxin preparations are heterogenous. Besides endotoxic components they contain non-toxic substances which are active in some of the beneficial effects attributed to endotoxins. These effects are immunopotentiation, enhanced proliferation of bone-marrow cells, resistance to infections, activation of the RES and increased resistance to a few experimental tumors. We found that this beneficial component (B component) of the commonly used LPS or ET preparation can be separated by chromatographic methods from the toxic component. Furthermore, we found that such B component can also be extracted directly from some rough mutant bacteria, from which the endotoxic components were previously removed.
The aim of this work is the characterization and chemical structural studies of the B component.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA024628-08
Application #
3166511
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1984-04-01
Project End
1994-11-30
Budget Start
1990-12-01
Budget End
1991-11-30
Support Year
8
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Dentistry
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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