Studies will be continued toward the completion of efficient synthetic routes to the trichothecins such as anguidine and verrucarol, as well as acyl-tetramic acids such as tirandamycin. The latter synthetic route will be modified so as to permit preparation of the related antitumor substance streptolydigan. In new studies to be initiated in the coming grant period, a synthetic approach to the complex aglycone tetronolide common to the tetracarcins a new class of antitumor compounds will be initiated. These studies also involve development of several new synthetic methods.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA029108-09A2
Application #
3168529
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1980-12-01
Project End
1995-02-28
Budget Start
1990-04-01
Budget End
1991-02-28
Support Year
9
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Rochester
Department
Type
Schools of Arts and Sciences
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627