Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA034443-12A1
Application #
2088675
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1984-07-01
Project End
2001-04-30
Budget Start
1996-07-01
Budget End
1997-04-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Organized Research Units
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Kim, Eunjung; Muga, Stephanie J; Fischer, Susan M (2004) Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene. J Biol Chem 279:11188-97
Fischer, Susan M; Conti, Claudio J; Viner, Jaye et al. (2003) Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis 24:945-52
Bol, David K; Rowley, R Bruce; Ho, Ching-Ping et al. (2002) Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. Cancer Res 62:2516-21
Fischer, Susan M (2002) Is cyclooxygenase-2 important in skin carcinogenesis? J Environ Pathol Toxicol Oncol 21:183-91
Kehrer, J P; Biswal, S S; La, E et al. (2001) Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J 356:899-906
Muga, S J; Thuillier, P; Pavone, A et al. (2000) 8S-lipoxygenase products activate peroxisome proliferator-activated receptor alpha and induce differentiation in murine keratinocytes. Cell Growth Differ 11:447-54
Martinez, L A; Chen, Y; Pavone, A et al. (2000) Deregulated expression of cyclin D1 overrides antimitogenic signals. Oncogene 19:315-22
Maldve, R E; Kim, Y; Muga, S J et al. (2000) Prostaglandin E(2) regulation of cyclooxygenase expression in keratinocytes is mediated via cyclic nucleotide-linked prostaglandin receptors. J Lipid Res 41:873-81
Kleymenova, E; Muga, S; Fischer, S et al. (2000) Application of high-performance liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis. Mol Carcinog 29:51-8
Li-Stiles, B; Fischer, S M (1999) Mechanism(s) of activation of secretory phospholipase A(2)s in mouse keratinocytes. J Lipid Res 40:1701-9

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