Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
2R01CA035368-12A1
Application #
2088934
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1983-07-01
Project End
2000-12-31
Budget Start
1996-02-06
Budget End
1996-12-31
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Hafeez, Bilal Bin; Meske, Louise; Singh, Ashok et al. (2016) Tissue-specific conditional PKC? knockout mice: a model to precisely reveal PKC? functional role in initiation, promotion and progression of cancer. Oncotarget 7:33069-80
Singh, Anupama; Singh, Ashok; Sand, Jordan M et al. (2015) Topically applied Hsp90 inhibitor 17AAG inhibits UVR-induced cutaneous squamous cell carcinomas. J Invest Dermatol 135:1098-1107
Hafeez, Bilal Bin; Jamal, Mohammad Sarwar; Fischer, Joseph W et al. (2012) Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-?B signaling pathways. Int J Cancer 131:2175-86
Sand, Jordan M; Bin Hafeez, Bilal; Jamal, Mohammad Sarwar et al. (2012) Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), isolated from Plumbago zeylanica, inhibits ultraviolet radiation-induced development of squamous cell carcinomas. Carcinogenesis 33:184-90
Sand, Jordan Marshall; Bin Hafeez, Bilal; Aziz, Moammir Hasan et al. (2012) Ultraviolet radiation and 12-O-tetradecanoylphorbol-13-acetate-induced interaction of mouse epidermal protein kinase Cýý with Stat3 involve integration with ERK1/2. Mol Carcinog 51:291-302
Hafeez, Bilal Bin; Zhong, Weixiong; Weichert, Jamey et al. (2011) Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res 71:2318-27
Aziz, M H; Hafeez, B B; Sand, J M et al. (2010) Protein kinase Cvarepsilon mediates Stat3Ser727 phosphorylation, Stat3-regulated gene expression, and cell invasion in various human cancer cell lines through integration with MAPK cascade (RAF-1, MEK1/2, and ERK1/2). Oncogene 29:3100-9
Sand, Jordan M; Aziz, Moammir H; Dreckschmidt, Nancy E et al. (2010) PKCepsilon overexpression, irrespective of genetic background, sensitizes skin to UVR-induced development of squamous-cell carcinomas. J Invest Dermatol 130:270-7
Aziz, Moammir Hasan; Sundling, Kaitlin Elizabeth; Dreckschmidt, Nancy Ellen et al. (2009) Protein kinase Cepsilon inhibits UVR-induced expression of FADD, an adaptor protein, linked to both Fas- and TNFR1-mediated apoptosis. J Invest Dermatol 129:2011-21
Aziz, Moammir H; Dreckschmidt, Nancy E; Verma, Ajit K (2008) Plumbagin, a medicinal plant-derived naphthoquinone, is a novel inhibitor of the growth and invasion of hormone-refractory prostate cancer. Cancer Res 68:9024-32

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