We have recently completed the interviewing of cases (n = 683) and controls (n = 1653) in a collaborative epidemiologic study of multiple myeloma (RO1 CA 23350). While the original grant did not provide for any resources to further characterize multiple myeloma (MM) cases according to immunoglobulin type and other parameters of their disease that might be indicative of etiologic heterogeneity, we were able to obtain these data on 43% of cases. Data from other studies and our preliminary analysis suggest that the separation of MM cases based on immunoglobulin type, in particular, could prove important, and that failure to examine cases according to immunoglobulin type could reduce the sensitivity of the investigation. Thus, this proposal requests funds for the completion of: (a) the ascertainment of clinical and laboratory data on the MM cases; and (b) the analysis that incorporates these data with those already obtained through interviews.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA035679-02
Application #
3173276
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1984-02-01
Project End
1986-01-31
Budget Start
1985-02-01
Budget End
1986-01-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
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Morris, P D; Koepsell, T D; Daling, J R et al. (1986) Toxic substance exposure and multiple myeloma: a case-control study. J Natl Cancer Inst 76:987-94