Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA036111-10S1
Application #
2089035
Study Section
Virology Study Section (VR)
Project Start
1983-12-01
Project End
1995-06-30
Budget Start
1993-12-01
Budget End
1995-06-30
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ruediger, Ralf; Zhou, Jin; Walter, Gernot (2007) Mutagenesis and expression of the scaffolding Aalpha and Abeta subunits of PP2A: assays for measuring defects in binding of cancer-related Aalpha and Abeta mutants to the regulatory B and catalytic C subunits. Methods Mol Biol 365:85-99
Walter, Gernot; Zhou, Jin; Ruediger, Ralf (2007) Purification of PP2A holoenzymes by sequential immunoprecipitation with anti-peptide antibodies. Methods Mol Biol 365:113-26
Petersen, Paris; Chou, Danny M; You, Zhongsheng et al. (2006) Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint. Mol Cell Biol 26:1997-2011
Zhou, Jin; Pham, Huong T; Walter, Gernot (2003) The formation and activity of PP2A holoenzymes do not depend on the isoform of the catalytic subunit. J Biol Chem 278:8617-22
Zhou, Jin; Pham, Huong T; Ruediger, Ralf et al. (2003) Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Biochem J 369:387-98
Chou, Danny M; Petersen, Paris; Walter, Johannes C et al. (2002) Protein phosphatase 2A regulates binding of Cdc45 to the prereplication complex. J Biol Chem 277:40520-7
Ruediger, R; Pham, H T; Walter, G (2001) Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene. Oncogene 20:10-5
Colella, S; Ohgaki, H; Ruediger, R et al. (2001) Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes. Int J Cancer 93:798-804
Ruediger, R; Pham, H T; Walter, G (2001) Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene. Oncogene 20:1892-9
Brewis, N; Ohst, K; Fields, K et al. (2000) Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. Am J Physiol Heart Circ Physiol 279:H1307-18

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