Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA040228-08S1
Application #
3179907
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1985-07-01
Project End
1995-05-31
Budget Start
1992-09-30
Budget End
1993-05-31
Support Year
8
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
Floyd, Robert A (2009) Serendipitous findings while researching oxygen free radicals. Free Radic Biol Med 46:1004-13
Baird, William M; Hooven, Louisa A; Mahadevan, Brinda (2005) Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action. Environ Mol Mutagen 45:106-14
Mahadevan, Brinda; Dashwood, Wan-Mohaiza; Luch, Andreas et al. (2003) Mutations induced by (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo[a,l]pyrene in the coding region of the hypoxanthine phosphoribosyltransferase (Hprt) gene in Chinese hamster V79 cells. Environ Mol Mutagen 41:131-9
Okazaki, Takao; Laali, Kenneth K; Zajc, Barbara et al. (2003) Stable ion study of benzo[a]pyrene (BaP) derivatives: 7,8-dihydro-BaP, 9,10-dihydro-BaP and its 6-halo derivatives, 1- and 3-methoxy-9,10-dihydro-BaP-7(8H)-one, as well as the proximate carcinogen BaP 7,8-dihydrodiol and its dibenzoate, combined with a co Org Biomol Chem 1:1509-16
Buters, Jeroen T M; Mahadevan, Brinda; Quintanilla-Martinez, Leticia et al. (2002) Cytochrome P450 1B1 determines susceptibility to dibenzo[a,l]pyrene-induced tumor formation. Chem Res Toxicol 15:1127-35
Mahadevan, B; Luch, A; Seidel, A et al. (2001) Effects of the (-)-anti-11R,12S-dihydrodiol 13S,14R-epoxide of dibenzo. Carcinogenesis 22:161-9
Melendez-Colon, V J; Luch, A; Seidel, A et al. (2000) Formation of stable DNA adducts and apurinic sites upon metabolic activation of bay and fjord region polycyclic aromatic hydrocarbons in human cell cultures. Chem Res Toxicol 13:7-Oct
Melendez-Colon, V J; Luch, A; Seidel, A et al. (1999) Comparison of cytochrome P450- and peroxidase-dependent metabolic activation of the potent carcinogen dibenzo[a,l]pyrene in human cell lines: formation of stable DNA adducts and absence of a detectable increase in apurinic sites. Cancer Res 59:1412-6
Luch, A; Kishiyama, S; Seidel, A et al. (1999) The K-region trans-8,9-diol does not significantly contribute as an intermediate in the metabolic activation of dibenzo[a,l]pyrene to DNA-binding metabolites by human cytochrome P450 1A1 or 1B1. Cancer Res 59:4603-9
Luch, A; Kudla, K; Seidel, A et al. (1999) The level of DNA modification by (+)-syn-(11S,12R,13S,14R)- and (-)-anti-(11R,12S,13S,14R)-dihydrodiol epoxides of dibenzo[a,l]pyrene determined the effect on the proteins p53 and p21WAF1 in the human mammary carcinoma cell line MCF-7. Carcinogenesis 20:859-65

Showing the most recent 10 out of 38 publications