Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA046565-02
Application #
3189856
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1988-02-01
Project End
1989-08-31
Budget Start
1989-02-06
Budget End
1989-08-31
Support Year
2
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Type
School of Medicine & Dentistry
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Chen, Chih-Chiun; Juric, Vladislava; Lau, Lester F (2011) The extracellular matrix protein CCN1 dictates TNF? and FasL cytotoxicity in vivo. Adv Exp Med Biol 691:595-603
Lau, Lester F (2011) CCN1/CYR61: the very model of a modern matricellular protein. Cell Mol Life Sci 68:3149-63
Jun, Joon-Il; Lau, Lester F (2010) Cellular senescence controls fibrosis in wound healing. Aging (Albany NY) 2:627-31
Jun, Joon-Il; Lau, Lester F (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12:676-85
Petrovic, Vladimir; Costa, Robert H; Lau, Lester F et al. (2010) Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biol Ther 9:1008-16
Chen, Chih-Chiun; Lau, Lester F (2010) Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. J Cell Commun Signal 4:63-9
Chen, Chih-Chiun; Lau, Lester F (2009) Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol 41:771-83
Juric, Vladislava; Chen, Chih-Chiun; Lau, Lester F (2009) Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Mol Cell Biol 29:3266-79
Franzen, Carrie A; Chen, Chih-Chiun; Todorovi?, Viktor et al. (2009) Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Mol Cancer Res 7:1045-55
Wang, I-Ching; Chen, Yi-Ju; Hughes, Douglas E et al. (2008) FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. J Biol Chem 283:20770-8

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