The limited successes in nonhuman primate studies in eliciting protective immunity against the AIDS virus by strategies that are safe for human use suggest that novel technologies may be needed to develop an HIV vaccine. Recent studies in small animal influenza models have indicated that DNA inoculation can induce potent protective anti-viral immunity. The simian immunodeficiency virus of macaques (SIVmac)-infected rhesus monkey has proven a powerful model system for assessing novel AIDS virus vaccine strategies. We will employ the SIVmac/rhesus monkey model to study the use of DNA vaccines for preventing HIV infection. Specifically, we will explore the: 1. Construction of SIVmac DNA vaccine vectors 2. Immunogenicity of these constructs 3. Novel DNA vaccine delivery systems 4. Combined modality immunization employing DNA vaccines 5. Protective immunity achieved through DNA vaccination

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA050139-07
Application #
2093615
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1989-03-17
Project End
1998-04-30
Budget Start
1995-05-01
Budget End
1996-04-30
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
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