Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA055008-02
Application #
3199432
Study Section
Pathology B Study Section (PTHB)
Project Start
1991-07-01
Project End
1992-08-31
Budget Start
1992-06-01
Budget End
1992-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
009214214
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Repasky, Gretchen A; Zhou, Yixing; Morita, Staeci et al. (2007) Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling. Mol Carcinog 46:958-70
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Murphy, Gretchen A; Graham, Suzanne M; Morita, Staeci et al. (2002) Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation. J Biol Chem 277:9966-75
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Solski, Patricia A; Helms, Whitney; Keely, Patricia J et al. (2002) RhoA biological activity is dependent on prenylation but independent of specific isoprenoid modification. Cell Growth Differ 13:363-73
Palmby, Todd R; Abe, Karon; Der, Channing J (2002) Critical role of the pleckstrin homology and cysteine-rich domains in Vav signaling and transforming activity. J Biol Chem 277:39350-9
Shields, Janiel M; Mehta, Heena; Pruitt, Kevin et al. (2002) Opposing roles of the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in Ras-mediated downregulation of tropomyosin. Mol Cell Biol 22:2304-17
Lambert, John M; Karnoub, Antoine E; Graves, Lee M et al. (2002) Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation. J Biol Chem 277:4770-7
Graham, S M; Rogers-Graham, K; Figueroa, C et al. (2001) Analyses of TC21/R-Ras2 signaling and biological activity. Methods Enzymol 333:203-16
Karnoub, A E; Der, C J; Campbell, S L (2001) The insert region of Rac1 is essential for membrane ruffling but not cellular transformation. Mol Cell Biol 21:2847-57

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