Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA058525-03
Application #
2099206
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1993-12-09
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Allegheny University of Health Sciences
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19129
Livezey, Kristin W; Negorev, Dmitri; Simon, Daniela (2002) Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene. Mutat Res 505:63-74
Fang, W; Piao, Z; Simon, D et al. (2000) Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p36.13-p36.23 and mutational analysis of the RIZ (PRDM2) gene localized to the region. Genes Chromosomes Cancer 28:269-75
Livezey, K W; Negorev, D; Simon, D (2000) Hepatitis B virus-transfected Hep G2 cells demonstrate genetic alterations and de novo viral integration in cells replicating HBV. Mutat Res 452:163-78
Livezey, K W; Negorev, D; Simon, D (2000) Investigation of the expression of Bin1, a putative suppressor, in human hepatoma cells. Cancer Genet Cytogenet 116:35-9
Hammond, C; Jeffers, L; Carr, B I et al. (1999) Multiple genetic alterations, 4q28, a new suppressor region, and potential gender differences in human hepatocellular carcinoma. Hepatology 29:1479-85
Livezey, K W; Simon, D (1997) Accumulation of genetic alterations in a human hepatoma cell line transfected with hepatitis B virus. Mutat Res 377:187-98
Negorev, D; Riethman, H; Wechsler-Reya, R et al. (1996) The Bin1 gene localizes to human chromosome 2q14 by PCR analysis of somatic cell hybrids and fluorescence in situ hybridization. Genomics 33:329-31
Simon, D; Carr, B I (1995) Integration of hepatitis B virus and alteration of the 1p36 region found in cancerous tissue of primary hepatocellular carcinoma with viral replication evidenced only in noncancerous, cirrhotic tissue. Hepatology 22:1393-8