Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
1R01CA069202-01
Application #
2113285
Study Section
Biochemistry Study Section (BIO)
Project Start
1996-07-01
Project End
2001-04-30
Budget Start
1996-07-01
Budget End
1997-04-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Yu, Zhi-Hong; Zhang, Zhong-Yin (2018) Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases. Chem Rev 118:1069-1091
Ruddraraju, Kasi Viswanatharaju; Zhang, Zhong-Yin (2017) Covalent inhibition of protein tyrosine phosphatases. Mol Biosyst 13:1257-1279
Zhang, Zhong-Yin (2017) Drugging the Undruggable: Therapeutic Potential of Targeting Protein Tyrosine Phosphatases. Acc Chem Res 50:122-129
Kobayashi, Michihiro; Nabinger, Sarah C; Bai, Yunpeng et al. (2017) Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors. Stem Cells 35:1053-1064
Kobayashi, M; Chen, S; Bai, Y et al. (2017) Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia. Leukemia 31:1453-1457
Yamashita, Naoya; Joshi, Rajshri; Zhang, Sheng et al. (2017) Phospho-Regulation of Soma-to-Axon Transcytosis of Neurotrophin Receptors. Dev Cell 42:626-639.e5
Frankson, Rochelle; Yu, Zhi-Hong; Bai, Yunpeng et al. (2017) Therapeutic Targeting of Oncogenic Tyrosine Phosphatases. Cancer Res 77:5701-5705
Kobayashi, M; Bai, Y; Chen, S et al. (2017) Phosphatase PRL2 promotes oncogenic NOTCH1-Induced T-cell leukemia. Leukemia 31:751-754
Sacchetti, Cristiano; Bai, Yunpeng; Stanford, Stephanie M et al. (2017) PTP4A1 promotes TGF? signaling and fibrosis in systemic sclerosis. Nat Commun 8:1060
He, Rongjun; Wang, Jifeng; Yu, Zhi-Hong et al. (2016) Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism. J Med Chem :

Showing the most recent 10 out of 123 publications