Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA079648-06S1
Application #
6935051
Study Section
Cancer Molecular Pathobiology Study Section (CAMP)
Program Officer
Rosenfeld, Bobby
Project Start
1999-01-18
Project End
2009-01-31
Budget Start
2004-06-01
Budget End
2005-01-31
Support Year
6
Fiscal Year
2004
Total Cost
$66,657
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030
Vélez-Cruz, Renier; Johnson, David G (2017) The Retinoblastoma (RB) Tumor Suppressor: Pushing Back against Genome Instability on Multiple Fronts. Int J Mol Sci 18:
Vélez-Cruz, Renier; Manickavinayaham, Swarnalatha; Biswas, Anup K et al. (2016) RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1. Genes Dev 30:2500-2512
Hossain, Mohammad B; Shifat, Rehnuma; Johnson, David G et al. (2016) TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv 2:e1501290
Biswas, Anup Kumar; Mitchell, David L; Johnson, David G (2014) E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis. Cancer Res 74:3369-77
Johnson, David G; Dent, Sharon Y R (2013) Chromatin: receiver and quarterback for cellular signals. Cell 152:685-9
Biswas, Anup K; Johnson, David G (2012) Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage. Cancer Res 72:13-7
Velez-Cruz, Renier; Johnson, David G (2012) E2F1 and p53 Transcription Factors as Accessory Factors for Nucleotide Excision Repair. Int J Mol Sci 13:13554-68
Guo, Ruifeng; Chen, Jie; Mitchell, David L et al. (2011) GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage. Nucleic Acids Res 39:1390-7
Chen, Jie; Zhu, Feng; Weaks, Regina L et al. (2011) E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaks. Cell Cycle 10:1287-94
Jiang, Yingjun; Wang, Xin; Bao, Shilai et al. (2010) INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc Natl Acad Sci U S A 107:17274-9

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