Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
3R01CA080250-07S1
Application #
6133815
Study Section
Pharmacology A Study Section (PHRA)
Program Officer
Spalholz, Barbara A
Project Start
1999-01-01
Project End
2003-12-31
Budget Start
1999-01-01
Budget End
1999-12-31
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Pharmacology
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Sotgia, Federica; Whitaker-Menezes, Diana; Martinez-Outschoorn, Ubaldo E et al. (2012) Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the ""reverse Warburg effect"" in positive lymph node tissue. Cell Cycle 11:1445-54
Capparelli, Claudia; Chiavarina, Barbara; Whitaker-Menezes, Diana et al. (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, ""fueling"" tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11:3599-610
Carito, Valentina; Bonuccelli, Gloria; Martinez-Outschoorn, Ubaldo E et al. (2012) Metabolic remodeling of the tumor microenvironment: migration stimulating factor (MSF) reprograms myofibroblasts toward lactate production, fueling anabolic tumor growth. Cell Cycle 11:3403-14
Guido, Carmela; Whitaker-Menezes, Diana; Lin, Zhao et al. (2012) Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget 3:798-810
Sotgia, Federica; Martinez-Outschoorn, Ubaldo E; Howell, Anthony et al. (2012) Caveolin-1 and cancer metabolism in the tumor microenvironment: markers, models, and mechanisms. Annu Rev Pathol 7:423-67
Chiavarina, Barbara; Martinez-Outschoorn, Ubaldo E; Whitaker-Menezes, Diana et al. (2012) Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1? and HIF2? in tumor-associated fibroblasts and human breast cancer cells. Cell Cycle 11:3280-9
Capparelli, Claudia; Guido, Carmela; Whitaker-Menezes, Diana et al. (2012) Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production. Cell Cycle 11:2285-302
Capparelli, Claudia; Whitaker-Menezes, Diana; Guido, Carmela et al. (2012) CTGF drives autophagy, glycolysis and senescence in cancer-associated fibroblasts via HIF1 activation, metabolically promoting tumor growth. Cell Cycle 11:2272-84
Mercier, Isabelle; Camacho, Jeanette; Titchen, Kanani et al. (2012) Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug. Am J Pathol 181:278-93
Pavlides, Stephanos; Vera, Iset; Gandara, Ricardo et al. (2012) Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 16:1264-84

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