Cigarette smoking is highly prevalent among persons with posttraumatic stress disorder (PTSD). Ambulatory and laboratory data collected during the last NCI R01CA8195 suggest that PTSD smokers' urges to smoke and smoking behavior may be particularly related to their symptomatology. Building upon this work and our newer pilot data, the current project will examine possible mechanisms of relapse in smokers with PTSD. Relapse continues to be a critical problem in smoking cessation treatment. Emerging evidence suggests that the majority of individuals attempting to quit smoking will relapse within the first or second week after quitting. Persons with PTSD may be at elevated risk for relapse due to a variety of factors including high levels of negative affect, attention problems, anxiety sensitivity, and poor distress tolerance or task persistence. Laboratory and ecological momentary assessment will be utilized to investigate antecedents of relapse and possible bio-behavioral predictors of relapse in smokers with PTSD. We propose to sample and compare smokers with and without PTSD, addressing the following three aims: 1) Investigate antecedents of smoking lapse and relapse, including ambulatory mood and PTSD symptoms; 2) Evaluate possible laboratory and psychological predictors of relapse including prepulse inhibition, anxiety sensitivity, measures of distress tolerance/task persistence and self-efficacy; and 3) Examine possible gender differences in ad lib smoking, antecedents of smoking lapse and relapse, and predictors of relapse. This study will potentially lead to benefits in multiple areas. First, this study should significantly advance knowledge about the antecedents and causes of smoking relapse in smokers with PTSD. Second, this information paired with a greater understanding of the mechanisms involved in ad lib smoking, may serve to inform development of specific smoking cessation strategies for this vulnerable population. Finally, by evaluating possible mechanisms that may be specific to or amplified in a psychiatric patient sample, we should gain a more complete understanding of the relationship between psychopathology and smoking behavior.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA081595-07
Application #
7368034
Study Section
Special Emphasis Panel (ZRG1-RPHB-H (91))
Program Officer
Augustson, Erik
Project Start
1998-09-30
Project End
2011-02-28
Budget Start
2008-03-01
Budget End
2009-02-28
Support Year
7
Fiscal Year
2008
Total Cost
$197,518
Indirect Cost
Name
Duke University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Van Voorhees, Elizabeth E; Dennis, Paul A; Elbogen, Eric B et al. (2018) Characterizing anger-related affect in individuals with posttraumatic stress disorder using ecological momentary assessment. Psychiatry Res 261:274-280
Dedert, Eric A; Hicks, Terrell A; Dennis, Paul A et al. (2016) Roles of inter-individual differences and intra-individual acute elevations in early smoking lapse in people with posttraumatic stress disorder. Addict Behav 60:171-6
Liu, Yutao; Garrett, Melanie E; Dennis, Michelle F et al. (2015) An examination of the association between 5-HTTLPR, combat exposure, and PTSD diagnosis among U.S. veterans. PLoS One 10:e0119998
Vrana, Scott R; Calhoun, Patrick S; Dennis, Michelle F et al. (2015) Acoustic startle and prepulse inhibition predict smoking lapse in posttraumatic stress disorder. J Psychopharmacol 29:1070-6
Volz, Angela R; Dennis, Paul A; Dennis, Michelle F et al. (2014) The role of daily hassles and distress tolerance in predicting cigarette craving during a quit attempt. Nicotine Tob Res 16:872-5
Van Voorhees, Elizabeth E; Dennis, Michelle F; Calhoun, Patrick S et al. (2014) Association of DHEA, DHEAS, and cortisol with childhood trauma exposure and post-traumatic stress disorder. Int Clin Psychopharmacol 29:56-62
Wilson, Sarah M; Dedert, Eric A; Dennis, Paul A et al. (2014) Do ethnicity and gender moderate the influence of posttraumatic stress disorder on time to smoking lapse? Addict Behav 39:1163-7
Dedert, Eric A; Dennis, Paul A; Swinkels, Cindy M et al. (2014) Ecological momentary assessment of posttraumatic stress disorder symptoms during a smoking quit attempt. Nicotine Tob Res 16:430-6
Van Voorhees, Elizabeth E; Dennis, Michelle F; McClernon, F Joseph et al. (2013) The association of dehydroepiandrosterone and dehydroepiandrosterone sulfate with anxiety sensitivity and electronic diary negative affect among smokers with and without posttraumatic stress disorder. J Clin Psychopharmacol 33:556-60
Vrana, Scott R; Calhoun, Patrick S; McClernon, F Joseph et al. (2013) Effects of smoking on the acoustic startle response and prepulse inhibition in smokers with and without posttraumatic stress disorder. Psychopharmacology (Berl) 230:477-85

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