While it has long been recognized that dietary factors play an important role in the etiology of cancer, information regarding the preventive potential of specific dietary compounds is scarce. The Shanghai Men's Health Study (SMHS) is a population-based cohort study of 61,582 Chinese men between 40 and 74 who lived in urban Shanghai at enrollment. Because intake levels of many suspected cancer-inhibitory dietary factors are high and diverse in Shanghai, the SMHS offers unique opportunities to fill such knowledge gaps. Detailed information on dietary and other lifestyle factors was collected at baseline and is being updated in a follow-up survey. Biological samples were collected from 89% of cohort members. The cohort has been followed for cancer occurrence and deaths via linkage with the population-based Shanghai Cancer Registry and the Shanghai Vital Statistics Unit, as well as through visits to all living cohort members every 2 years. We propose in this renewal application to extend the follow-up of this cohort for 5 more years and to evaluate dietary hypotheses for the lung, stomach, and colorectal (CRC). The primary focus of the study is to determine whether regular tea consumption and high intake of folate, soy foods, allium vegetables, and crucifers are associated with a reduced risk of cancer. We also propose to conduct a nested case-control study to evaluate whether the levels of blood folate, urinary phytoestrogens (CRC only) and isothiocyanate are inversely associated with the risk of cancers of colorectum, lung, and stomach. These biomarkers are aggregate measures of level of intake, absorption, and metabolism and will provide added insight in elucidating the relationship of dietary factors with cancer risk. Blood level C-reactive protein and H.pylori antibodies will also be evaluated in the nested case-control study for CRC and stomach cancer. Finally, we propose to re-survey all living cohort-members to update information on usual dietary intake and other lifestyle factors to refine exposure assessments and to characterize and evaluate how temporal changes in exposures may influence cancer risk. Because of its size, setting, and unique exposure patterns and biological specimens, the SMHS provides an exceptional opportunity to address dietary hypotheses for cancer that cannot be adequately investigated in any other existing cohort study. The results from this study may guide new strategies in the primary prevention of common cancers in both Western and Asian men.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-HOP-N (03))
Program Officer
Mahabir, Somdat
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Vanderbilt University Medical Center
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Varga, Matthew G; Cai, Hui; Waterboer, Tim et al. (2018) Epstein-Barr Virus Antibody Titers Are Not Associated with Gastric Cancer Risk in East Asia. Dig Dis Sci 63:2765-2772
Wu, Lang; Zheng, Wei; Xiang, Yong-Bing et al. (2018) Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies. Cancer Epidemiol Biomarkers Prev 27:479-487
Luu, Hung N; Cai, Hui; Murff, Harvey J et al. (2018) A prospective study of dietary polyunsaturated fatty acids intake and lung cancer risk. Int J Cancer 143:2225-2237
Theofylaktopoulou, Despoina; Midttun, Øivind; Ueland, Per M et al. (2018) Impaired functional vitamin B6 status is associated with increased risk of lung cancer. Int J Cancer 142:2425-2434
Zhang, Qing-Li; Zhao, Long-Gang; Li, Hong-Lan et al. (2018) The joint effects of major lifestyle factors on colorectal cancer risk among Chinese men: A prospective cohort study. Int J Cancer 142:1093-1101
Varga, Matthew G; Wang, Tianyi; Cai, Hui et al. (2018) Helicobacter pylori Blood Biomarkers and Gastric Cancer Survival in China. Cancer Epidemiol Biomarkers Prev 27:342-344
Muller, D C; Hodge, A M; Fanidi, A et al. (2018) No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3). Ann Oncol 29:1468-1475
Dai, Fei; Cai, Hui; Li, Honglan et al. (2017) Association of sleep duration and incidence of diabetes modified by tea consumption: a report from the Shanghai men's health study. Sleep Med 38:135-141
Shu, Xiang; Cai, Hui; Xiang, Yong-Bing et al. (2017) Nephrolithiasis Among Middle Aged and Elderly Urban Chinese: A Report from Prospective Cohort Studies in Shanghai. J Endourol 31:1327-1334
Cui, Yong; Shu, Xiao-Ou; Li, Hong-Lan et al. (2017) Prospective study of urinary prostaglandin E2 metabolite and pancreatic cancer risk. Int J Cancer 141:2423-2429

Showing the most recent 10 out of 138 publications