This proposal describes the development of an efficient synthesis of the pharmaceutical agents related to morphine. The major focus will be on the use of the intramolecular addition of enolates to pyridinium ions for the preparation of benzofuroisoquinolines, key morphine precursors, and the exploration of the efficient control of absolute stereochemistry which is possible due to the reversibility of this reaction. The conversion of the benzofuroisoquinolines into the morphine alkaloids will be addressed. New approaches to the morphine system will also be studied.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA002708-07
Application #
3207523
Study Section
(DABB)
Project Start
1980-07-01
Project End
1989-06-30
Budget Start
1988-07-01
Budget End
1989-06-30
Support Year
7
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Oregon State University
Department
Type
Schools of Arts and Sciences
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339