The research is designed to assess the relationship between the reinforcing properties of psychoactive drugs and personality, mood states and subjective reactions to the drugs in humans. These relationships will be assesed in a situation where subjects are given an opportunity to choose to ingest one of two available drugs with concurrent measurements of subjective effects. In one group of studies these relationships will be investigated in specific populations of subjects (anxious, depressed, overweight and heavy drinkers) using stimulants and anxiolytics. If reinforcing effects are greater in certain populations of subjects this may indicate that they are at a greater risk for dependence. In other studies, a similar preference procedure will be used with subjects remaining in the laboratory in order to test a broad spectrum of drugs including anxiolytics, stimulants, barbiturates, alcohol and opiates. The purpose of these studies is to further refine our methods for determining the dependence potential of drugs and as well, to use these methods to determine whether there are certain individuals who possess psychological characteristics which put them at greater risk for excessive drug use.
| Doss, Manoj K; Weafer, Jessica; Ruiz, Nicholas A et al. (2018) Alcohol and pharmacologically similar sedatives impair encoding and facilitate consolidation of both recollection and familiarity in episodic memory. Cogn Neurosci 9:89-99 |
| de Wit, Harriet; Epstein, David H; Preston, Kenzie L (2018) Does human language limit translatability of clinical and preclinical addiction research? Neuropsychopharmacology 43:1985-1988 |
| Crane, Natania A; Gorka, Stephanie M; Weafer, Jessica et al. (2018) Neural activation to monetary reward is associated with amphetamine reward sensitivity. Neuropsychopharmacology 43:1738-1744 |
| Doss, Manoj K; Weafer, Jessica; Gallo, David A et al. (2018) MDMA Impairs Both the Encoding and Retrieval of Emotional Recollections. Neuropsychopharmacology 43:791-800 |
| Bershad, Anya K; Miller, Melissa A; Norman, Greg J et al. (2018) Effects of opioid- and non-opioid analgesics on responses to psychosocial stress in humans. Horm Behav 102:41-47 |
| Vena, Ashley; King, Andrea; Lee, Royce et al. (2018) Intranasal Oxytocin Does Not Modulate Responses to Alcohol in Social Drinkers. Alcohol Clin Exp Res 42:1725-1734 |
| de Wit, Harriet; Sayette, Michael (2018) Considering the context: social factors in responses to drugs in humans. Psychopharmacology (Berl) 235:935-945 |
| Childs, Emma; Astur, Robert S; de Wit, Harriet (2017) Virtual reality conditioned place preference using monetary reward. Behav Brain Res 322:110-114 |
| Bershad, Anya K; Miller, Melissa A; de Wit, Harriet (2017) MDMA does not alter responses to the Trier Social Stress Test in humans. Psychopharmacology (Berl) 234:2159-2166 |
| Weafer, Jessica; Lyon, Nicholas; Hedeker, Donald et al. (2017) Sweet taste liking is associated with subjective response to amphetamine in women but not men. Psychopharmacology (Berl) 234:3185-3194 |
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