Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
7R01DA005195-06
Application #
2117500
Study Section
Drug Abuse Biomedical Research Review Committee (DABR)
Project Start
1989-09-30
Project End
1996-06-30
Budget Start
1995-03-16
Budget End
1995-06-30
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Patkar, Kshitij A; Murray, Thomas F; Aldrich, Jane V (2009) The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem 52:6814-21
Bennett, M A; Murray, T F; Aldrich, J V (2005) Structure-activity relationships of arodyn, a novel acetylated kappa opioid receptor antagonist. J Pept Res 65:322-32
Patkar, Kshitij A; Yan, Xiuzhen; Murray, Thomas F et al. (2005) [Nalpha-benzylTyr1,cyclo(D-Asp5,Dap8)]- dynorphin A-(1-11)NH2 cyclized in the ""address"" domain is a novel kappa-opioid receptor antagonist. J Med Chem 48:4500-3
Vig, Balvinder S; Murray, Thomas F; Aldrich, Jane V (2004) Synthesis and opioid activity of side-chain-to-side-chain cyclic dynorphin A-(1-11) amide analogues cyclized between positions 2 and 5. 1. Substitutions in position 3. J Med Chem 47:446-55
Vig, Balvinder S; Murray, Thomas F; Aldrich, Jane V (2003) Synthesis of novel basic head-to-side-chain cyclic dynorphin A analogs: strategies and side reactions. Biopolymers 71:620-37
Bennett, Marco A; Murray, Thomas F; Aldrich, Jane V (2002) Identification of arodyn, a novel acetylated dynorphin A-(1-11) analogue, as a kappa opioid receptor antagonist. J Med Chem 45:5617-9
Choi, H; Murray, T F; DeLander, G E et al. (1997) Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution. J Med Chem 40:2733-9
Arttamangkul, S; Ishmael, J E; Murray, T F et al. (1997) Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 2. Conformational constraint in the ""address"" sequence. J Med Chem 40:1211-8
Arttamangkul, S; Murray, T F; DeLander, G E et al. (1995) Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the ""message"" sequence. J Med Chem 38:2410-7
Story, S C; Aldrich, J V (1994) Side-product formation during cyclization with HBTU on a solid support. Int J Pept Protein Res 43:292-6

Showing the most recent 10 out of 15 publications