Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA005412-01
Application #
3211738
Study Section
Pharmacology I Research Subcommittee (DABR)
Project Start
1987-09-30
Project End
1990-08-31
Budget Start
1987-09-30
Budget End
1988-08-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Ikeda, Hiroko; Miyatake, Mayumi; Koshikawa, Noriaki et al. (2010) Morphine modulation of thrombospondin levels in astrocytes and its implications for neurite outgrowth and synapse formation. J Biol Chem 285:38415-27
Hahn, Jason W; Jagwani, Shana; Kim, Eunhae et al. (2010) Mu and kappa opioids modulate mouse embryonic stem cell-derived neural progenitor differentiation via MAP kinases. J Neurochem 112:1431-41
Miyatake, Mayumi; Rubinstein, Tal J; McLennan, Gregory P et al. (2009) Inhibition of EGF-induced ERK/MAP kinase-mediated astrocyte proliferation by mu opioids: integration of G protein and beta-arrestin 2-dependent pathways. J Neurochem 110:662-74
McLennan, Gregory P; Kiss, Alexi; Miyatake, Mayumi et al. (2008) Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. J Neurochem 107:1753-65
Kim, Eunhae; Clark, Amy L; Kiss, Alexi et al. (2006) Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem 281:33749-60
Belcheva, Mariana M; Clark, Amy L; Haas, Paul D et al. (2005) Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem 280:27662-9
Belcheva, Mariana M; Tan, Yun; Heaton, Virginia M et al. (2003) Mu opioid transactivation and down-regulation of the epidermal growth factor receptor in astrocytes: implications for mitogen-activated protein kinase signaling. Mol Pharmacol 64:1391-401
Belcheva, Mariana M; Haas, Paul D; Tan, Yun et al. (2002) The fibroblast growth factor receptor is at the site of convergence between mu-opioid receptor and growth factor signaling pathways in rat C6 glioma cells. J Pharmacol Exp Ther 303:909-18
Fabian, G; Bozo, B; Szikszay, M et al. (2002) Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain. J Pharmacol Exp Ther 302:774-80
Belcheva, Mariana M; Coscia, Carmine J (2002) Diversity of G protein-coupled receptor signaling pathways to ERK/MAP kinase. Neurosignals 11:34-44

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