Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA006784-12
Application #
6624749
Study Section
Special Emphasis Panel (ZRG1-MDCN-5 (01))
Program Officer
Frankenheim, Jerry
Project Start
1991-04-01
Project End
2004-11-30
Budget Start
2002-12-01
Budget End
2003-11-30
Support Year
12
Fiscal Year
2003
Total Cost
$240,620
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
937727907
City
Winston-Salem
State
NC
Country
United States
Zip Code
27157
Vardanyan, Ruben; Vijay, Gokhale; Nichol, Gary S et al. (2009) Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain. Bioorg Med Chem 17:5044-53
Childers, Steven R (2006) Activation of G-proteins in brain by endogenous and exogenous cannabinoids. AAPS J 8:E112-7
Howlett, Allyn C; Breivogel, Christopher S; Childers, Steven R et al. (2004) Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology 47 Suppl 1:345-58
Breivogel, Christopher S; Walker, J Michael; Huang, Susan M et al. (2004) Cannabinoid signaling in rat cerebellar granule cells: G-protein activation, inhibition of glutamate release and endogenous cannabinoids. Neuropharmacology 47:81-91
Sim-Selley, Laura J; Vogt, Leslie J; Vogt, Brent A et al. (2002) Cellular localization of cannabinoid receptors and activated G-proteins in rat anterior cingulate cortex. Life Sci 71:2217-26
Sim-Selley, Laura J; Childers, Steven R (2002) Neuroanatomical localization of receptor-activated G proteins in brain. Methods Enzymol 344:42-58
Prather, P L; Martin, N A; Breivogel, C S et al. (2000) Activation of cannabinoid receptors in rat brain by WIN 55212-2 produces coupling to multiple G protein alpha-subunits with different potencies. Mol Pharmacol 57:1000-10
Breivogel, C S; Childers, S R (2000) Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition. J Pharmacol Exp Ther 295:328-36
Breivogel, C S; Childers, S R; Deadwyler, S A et al. (1999) Chronic delta9-tetrahydrocannabinol treatment produces a time-dependent loss of cannabinoid receptors and cannabinoid receptor-activated G proteins in rat brain. J Neurochem 73:2447-59
Childers, S R; Breivogel, C S (1998) Cannabis and endogenous cannabinoid systems. Drug Alcohol Depend 51:173-87

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