The revised application proposes a five-year extension of the Early Steps Multisite Project (ES-M) focused on Understanding and Preventing Childhood Drug Use Risk. The ES-M project is a collaboration of the Child and Family Center at the University of Oregon (Dishion), the University of Pittsburgh (Shaw), and the University of Virginia (Wilson). During its first five years the project exceeded expected recruitment rates (731), maintained high retention rates (85%), successfully engaged families in our family-intervention model, and produced reductions in problem behavior and emotion distress in children from ages 2 to 4 years. We have found that improvements in children's adjustment were mediated by improved family management practices. In the next five years we propose to adapt the family intervention model to provide support for each child's transition into the public school system, and conduct developmental analyses to better understand early emergence of school competence, early deviant peer involvement problem behavior, and emotion distress. We will also address the role of siblings in children's development and as an intervention outcome variable. Biannual intensive assessments are proposed that include home visits and direct observations, as well as yearly assessments of the child's problem behavior and self-regulation in the family context. This assessment builds on an existing multiagent-multimethod assessment strategy across all three sites that has included yearly direct observations as well as measurement of child and family characteristics. We propose that the study will test the effectiveness of a feasible, cost-effective, family-centered intervention that can be initiated within WIC or similar service settings and be continued and maintained in the public school environment. In addition, the data set affords a rich opportunity to link caregiver engagement in the intervention with child and family outcomes. The net effect of this family-centered, early intervention strategy is significant reduction of risk for early-onset problem behavior, improved school competence, reduction in children's mental health disorders, and reductions in risk for drug use from age 2 to 10. Advancements in multivariate data analysis such as general growth mixture modeling will be used to study the environmental factors associated with the formation of health and of high-risk developmental trajectories, as well as to determine the effectiveness of the family intervention in altering those trajectories. ? ? ?

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Study Section
Human Development Research Subcommittee (NIDA)
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Sims, Belinda E
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University of Oregon
Other Health Professions
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United States
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Smith, Justin D; Berkel, Cady; Hails, Katherine A et al. (2018) Predictors of Participation in the Family Check-Up Program: a Randomized Trial of Yearly Services from Age 2 to 10 Years. Prev Sci 19:652-662
Shelleby, Elizabeth C; Shaw, Daniel S; Dishion, Thomas J et al. (2018) Effects of the Family Check-Up on reducing growth in conduct problems from toddlerhood through school age: An analysis of moderated mediation. J Consult Clin Psychol 86:856-867
Otten, Roy; Mun, Chung Jung; Shaw, Daniel S et al. (2018) A developmental cascade model for early adolescent-onset substance use: the role of early childhood stress. Addiction :
Hails, Katherine A; Reuben, Julia D; Shaw, Daniel S et al. (2017) Transactional Associations Among Maternal Depression, Parent-Child Coercion, and Child Conduct Problems During Early Childhood. J Clin Child Adolesc Psychol :1-15
McIntyre, Laura Lee; Pelham 3rd, William E; Kim, Matthew H et al. (2017) A Brief Measure of Language Skills at 3 Years of Age and Special Education Use in Middle Childhood. J Pediatr 181:189-194
Shaw, Daniel S; Sitnick, Stephanie L; Reuben, Julia et al. (2016) Transactional effects among maternal depression, neighborhood deprivation, and child conduct problems from early childhood through adolescence: A tale of two low-income samples. Dev Psychopathol 28:819-36
Shaw, Daniel S; Sitnick, Stephanie L; Brennan, Lauretta M et al. (2016) The long-term effectiveness of the Family Check-Up on school-age conduct problems: Moderation by neighborhood deprivation. Dev Psychopathol 28:1471-1486
Chiapa, Amanda; Parra Morris, Georgina; Véronneau, Marie Hélène et al. (2016) Translational research on parenting of adolescents: Linking theory to valid observation measures for family centered prevention and treatment. Transl Behav Med 6:90-104
Smith, Justin D; Dishion, Thomas J; Brown, Kimbree et al. (2016) An Experimental Study of Procedures to Enhance Ratings of Fidelity to an Evidence-Based Family Intervention. Prev Sci 17:62-70
Waller, Rebecca; Dishion, Thomas J; Shaw, Daniel S et al. (2016) Does early childhood callous-unemotional behavior uniquely predict behavior problems or callous-unemotional behavior in late childhood? Dev Psychol 52:1805-1819

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