The purpose of this longitudinal, multi-method study is to investigate the impact of prenatal exposure to cigarettes on the development of self-regulation over the first 2 years of life. Because most women who smoke cigarettes during pregnancy also have partners who smoke, children's exposure to environmental tobacco smoke (ETS) will also be examined. Cigarette exposure has been associated with a number of regulatory outcomes such as behavior problems, conduct disorder, and attention problems in later childhood. However, little is known about the developmental pathways to these self-regulatory outcomes among cigarette exposed children or about mediators and moderators of risk.
Specific aims of this study are as follows: 1) examine direct effects of prenatal and ETS exposure on child regulation;2) examine the association between prenatal exposure and language development and the association between language development and self-regulation at 24 months;3) examine the role of parenting as the proximal mediator of the association between cigarette exposure and child outcomes such as reactivity and regulation at 9 and 16 months and self-regulation at 24 months;4) examine if a cumulative family risk score, including parenting, moderates the association between cigarette exposure and child outcomes. The final sample will consist of 150 women who smoke during pregnancy and 100 non-smoking women with no ETS exposure recruited prenatally, and followed for 2 years postnatally. Assessments of physiological and behavioral reactivity and regulation will be conducted at 2, 9, and 16 months of age. These include autonomic measures such as respiratory sinus arrythmia during sleep at 2 months, and during affect arousing procedures at 9 and 16 months, as well as observational assessments of reactivity and regulation of arousal. In addition, assessments of focused attention using both physiolgoical (e.g., Heart Rate) and observational measures will be conducted at 9 and 16 months. Finally, assessments of toddler self-regulation (effortful control, compliance, behavior problems, and internalization of rules) and language development will be conducted at 24 months of age. Parenting and risk variables will be assessed at each age as potential mediators or moderators of risk. The study is guided by a developmental psychopathology framework and transactional models of child development emphasizing multiple pathways to risk. It is anticipated that this study will enrich our understanding of pathways to self-regulatory problems among children of cigarette smoking mothers and reasons for heterogeneity in outcomes among cigarette exposed toddlers.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPHB-H (90))
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Sirocco, Karen
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State University of New York at Buffalo
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Massey, Suena H; Mroczek, Daniel K; Reiss, David et al. (2018) Additive drug-specific and sex-specific risks associated with co-use of marijuana and tobacco during pregnancy: Evidence from 3 recent developmental cohorts (2003-2015). Neurotoxicol Teratol 68:97-106
Terai, Hideki; Kitajima, Shunsuke; Potter, Danielle S et al. (2018) ER Stress Signaling Promotes the Survival of Cancer ""Persister Cells"" Tolerant to EGFR Tyrosine Kinase Inhibitors. Cancer Res 78:1044-1057
Eiden, Rina D; Schuetze, Pamela; Shisler, Shannon et al. (2018) Prenatal exposure to tobacco and cannabis: Effects on autonomic and emotion regulation. Neurotoxicol Teratol 68:47-56
Colder, Craig R; Shyhalla, Kathleen; Frndak, Seth E (2018) Early alcohol use with parental permission: Psychosocial characteristics and drinking in late adolescence. Addict Behav 76:82-87
Schuetze, Pamela; Eiden, Rina D; Colder, Craig R et al. (2018) Prenatal Risk and Infant Regulation: Indirect Pathways via Fetal Growth and Maternal Prenatal Stress and Anger. Child Dev 89:e123-e137
Eiden, Rina D; Zhao, Junru; Casey, Meghan et al. (2018) Pre- and postnatal tobacco and cannabis exposure and child behavior problems: Bidirectional associations, joint effects, and sex differences. Drug Alcohol Depend 185:82-92
Molnar, Danielle S; Granger, Douglas A; Shisler, Shannon et al. (2018) Prenatal and postnatal cigarette and cannabis exposure: Effects on Secretory Immunoglobulin A in early childhood. Neurotoxicol Teratol 67:31-36
Godleski, Stephanie A; Shisler, Shannon; Eiden, Rina D et al. (2018) Co-use of tobacco and marijuana during pregnancy: Pathways to externalizing behavior problems in early childhood. Neurotoxicol Teratol 69:39-48
Shisler, Shannon; Eiden, Rina D; Molnar, Danielle S et al. (2017) Smoking in Pregnancy and Fetal Growth: The Case for More Intensive Assessment. Nicotine Tob Res 19:525-531
Molnar, Danielle S; Rancourt, Diana; Schlauch, Robert et al. (2017) Tobacco Exposure and Conditional Weight-for-Length Gain by 2 Years of Age. J Pediatr Psychol 42:679-688

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