Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC002236-02
Application #
2127471
Study Section
Hearing Research Study Section (HAR)
Project Start
1995-01-01
Project End
1998-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hurle, Belen; Marques-Bonet, Tomas; Antonacci, Francesca et al. (2011) Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses. BMC Evol Biol 11:23
Kim, Euysoo; Hyrc, Krzysztof L; Speck, Judith et al. (2011) Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells. Mol Cell Neurosci 46:655-61
Lu, Wenfu; Zhou, Dan; Freeman, John J et al. (2010) In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure. Hear Res 268:172-83
Kim, Euysoo; Hyrc, Krzysztof L; Speck, Judith et al. (2010) Regulation of cellular calcium in vestibular supporting cells by otopetrin 1. J Neurophysiol 104:3439-50
Hughes, Inna; Binkley, Jonathan; Hurle, Belen et al. (2008) Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members. BMC Evol Biol 8:41
Hughes, Inna; Saito, Mitsuyoshi; Schlesinger, Paul H et al. (2007) Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium. Proc Natl Acad Sci U S A 104:12023-8
Thalmann, Isolde; Hughes, Inna; Tong, Benton D et al. (2006) Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti. Electrophoresis 27:1598-608
Hughes, Inna; Thalmann, Isolde; Thalmann, Ruediger et al. (2006) Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res 1091:58-74
Hughes, Inna; Blasiole, Brian; Huss, David et al. (2004) Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio. Dev Biol 276:391-402
Ignatova, Elena G; Thalmann, Isolde; Xu, Baogang et al. (2004) Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice. Hear Res 194:65-72

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