The long-term objectives of this research program are to understand how temporal patterns in communication sounds are represented and processed in the central auditory system. Much of the information in communication signals, including human language, resides in their temporal structure. An understanding of how the temporal structure of sounds is represented and processed in the nervous system, therefore, is vital to understanding the neural bases of communication and communicative disorders. The research will be conducted on the auditory system of anurans because the temporal structure of their vocalizations has been shown to be important in their reproductive biology and behavioral studies can be conducted to delineate their temporal processing abilities. Presently, little is known concernng the neural mechanisms of temporal processing in the auditory system. At a basic level, the temporal structure of sound consists of how its amplitude and frequency changes, i.e., is modulated, over time. The specific goals of this research are to gain insight into how amplitude modulations are represeted in the brain and the transformations in these representations. In a number of vertebrate species, including mammals, there is a transformation from a periodicity coding of the rate of amplitude modulation to an AM filter representation; most neurons in the midbrain respond best over a particular range of AM rate, i.e., are band-pass. The mechanisms underlying this transformation are poorly understood. The specific experiments outlined in this research proposal are designed to test hypotheses concerning the generation of band-pass AM selectivity. The roles of recovery processes and temporal integration will be investigated. Other experiments should reveal whether an 'AM map' exists in the midbrain.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Special Emphasis Panel (ZRG1-IFCN-6 (01))
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Luethke, Lynn E
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University of Utah
Schools of Arts and Sciences
Salt Lake City
United States
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Alluri, Rishi K; Rose, Gary J; Hanson, Jessica L et al. (2016) Phasic, suprathreshold excitation and sustained inhibition underlie neuronal selectivity for short-duration sounds. Proc Natl Acad Sci U S A 113:E1927-35
Rose, Gary J; Alluri, Rishi K; Vasquez-Opazo, Gustavo A et al. (2013) Combining pharmacology and whole-cell patch recording from CNS neurons, in vivo. J Neurosci Methods 213:99-104
Rose, Gary J; Leary, Christopher J; Edwards, Christofer J (2011) Interval-counting neurons in the anuran auditory midbrain: factors underlying diversity of interval tuning. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 197:97-108
Leary, Christopher J; Edwards, Christofer J; Rose, Gary J (2008) Midbrain auditory neurons integrate excitation and inhibition to generate duration selectivity: an in vivo whole-cell patch study in anurans. J Neurosci 28:5481-93
Alder, T B; Rose, G J (2000) Integration and recovery processes contribute to the temporal selectivity of neurons in the midbrain of the northern leopard frog, Rana pipiens. J Comp Physiol A 186:923-37