Recent studies have demonstrated a link between low peak bone mass in early adulthood and osteoporosis later in life. Studies have indicated that calcium (Ca) intake and exercise patterns may be associated with bone mass and density in older children and adults, and that fluoride (F) may affect adult bone. However, few studies included younger children and none have examined the effects of F or Ca intake and genetic factors on bone mass/density in this age group. The goals of this project are to characterize biologic variation in bone development in healthy young children, and to understand how nutritional, behavioral, genetic and other factors interact to influence bone accretion in childhood, leading to attainment of peak bone mass in early adulthood. A cohort of 400 children already participating in a NIDR-funded longitudinal study of fluoride intake and dental fluorosis (NIDR RO1-DE09551) will be studied. Detailed information about daily intakes of F, Ca, Vitamin D, and other nutrients, and medical history is already available for each child since birth. We will continue to collect these data at 4 month intervals, and will collect exercise data for each child. To assess acquisition of bone mass over time, bone density measurements of the lumbar spine, hip, and whole body will be made, using dual-energy x-ray absorptiometry at age 4-5 years, and again at 7-8 years. Allelic variation of 6 bone-related genes will be determined by PCR-based assays, with whole blood DNA as template. Bivariate and multivariate analyses will be used to identify major modifiers of bone mass/density and bone accretion, and to examine potential interactions among these factors as they relate to bone acquisition. This study offers a unique opportunity to provide valuable insight into bone development in children, using a well-organized existing cohort for which extensive data are already available. Our results could serve as a basis for future recommendations regarding modifiable factors (such as nutrient intake and exercise) for enhancement of bone mass/density, and thereby may have important implications for prevention of adult-onset conditions such as osteoporosis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
1R01DE012101-01A2
Application #
2611578
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1998-04-01
Project End
2003-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Iowa
Department
Dentistry
Type
Schools of Dentistry
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Glass, Natalie A; Torner, James C; Letuchy, Elena M et al. (2018) Does Visceral or Subcutaneous Fat Influence Peripheral Cortical Bone Strength During Adolescence? A Longitudinal Study. J Bone Miner Res 33:580-588
Curtis, Alexandra M; VanBuren, John; Cavanaugh, Joseph E et al. (2018) Longitudinal associations between dental caries increment and risk factors in late childhood and adolescence. J Public Health Dent 78:321-328
Ballantine, Jami L; Carlson, Jenna C; Ferreira Zandoná, Andrea G et al. (2018) Exploring the genomic basis of early childhood caries: a pilot study. Int J Paediatr Dent 28:217-225
Lorenz, Douglas J; Levy, Steven; Datta, Somnath (2018) Inferring marginal association with paired and unpaired clustered data. Stat Methods Med Res 27:1806-1817
Oweis, Reem Reda; Levy, Steven M; Eichenberger-Gilmore, Julie M et al. (2018) Fluoride intake and cortical and trabecular bone characteristics in adolescents at age 17: A prospective cohort study. Community Dent Oral Epidemiol 46:527-534
Curtis, A M; Cavanaugh, J E; Levy, S M et al. (2018) Examining caries aetiology in adolescence with structural equation modelling. Community Dent Oral Epidemiol 46:258-264
Choo-Wosoba, Hyoyoung; Gaskins, Jeremy; Levy, Steven et al. (2018) A Bayesian approach for analyzing zero-inflated clustered count data with dispersion. Stat Med 37:801-812
Haworth, Simon; Shungin, Dmitry; van der Tas, Justin T et al. (2018) Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum Mol Genet 27:3113-3127
Govil, Manika; Mukhopadhyay, Nandita; Weeks, Daniel E et al. (2018) Novel caries loci in children and adults implicated by genome-wide analysis of families. BMC Oral Health 18:98
Levy, Steven M; Eichenberger-Gilmore, Julie M; Warren, John J et al. (2018) Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11. J Public Health Dent 78:352-359

Showing the most recent 10 out of 107 publications