The need for biomaterials has increased as the world population ages. Calcium phosphate cements (CPC) are highly promising for wide clinical applications due to their osteoconductivity and bone replacement capability.Their low strength, however, limits CPC to only non-stress uses. A literature search revealed no study on fiber reinforcement of CPC. In preliminary studies, the promise for CPC reinforcement was shown with a 2- to 5-fold increase in strength, 6-fold increase in fracture toughness, and two orders of magnitude increase in work-of-fracture. In this project, Aim 1 will use absorbable fibers to strengthen CPC and then to dissolve and create microprocessor vascular ingrowth; the effects of fiber length, volume fraction and fiber-matrix interface will be studied.
Aim 2 vill study the effects of changes in the absorbable fiber properties on the composite properties, and establish predictive equations.
In Aim 3, CPC matrices with wide property ranges will be used to establish the relationships between matrix and composite properties. Non-rigid CPC, fast-dissolution CPC, flow able CPC and macroporous CPC will be studied; models on fundamental structure-property relationships will be determined.
Aim 4 will investigate novel methods to control the macropore formation rate and tailor the strength history of the implant. Faster-absorbable fibers and slow-absorbable fibers will be combined in CPC for a high initial strength. Then the faster fibers dissolve and create macropores for bony ingrowth, while the slow fibers provide longer-term strength. Modeling will be performed to relate the composite property change to that of each fiber.
In Aim 5, absorbable meshes will be used in CPC for strength and then highly interconnected macropores. The effects of mesh thickness and strength changes in immersion will be investigated and predictive equations will be established. Functionally graded multilayer implants will be investigated using mesh and fibers for controlled strength and macropore formation gradient. These studies will: 1) Yield novel composites for Dental and craniofacial repairs with superior strength, self-setting ability, scaffold structures, and capability of resorption and replacement by new bone; (it) Establish microstructural design methods for implants to achieve high strength and toughness with tailored strength history and macropore formation rates; (iii) Provide new reinforcement mechanisms, fundamental composite-constituent relationships, predictive models, and processing guidance to form the basis for a new generation of biomaterials.

National Institute of Health (NIH)
National Institute of Dental & Craniofacial Research (NIDCR)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-OBM-1 (01))
Program Officer
Drummond, James
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
American Dental Association Foundation
United States
Zip Code
Qin, Wei; Gao, Xianling; Ma, Tao et al. (2018) Metformin Enhances the Differentiation of Dental Pulp Cells into Odontoblasts by Activating AMPK Signaling. J Endod 44:576-584
Xia, Yang; Chen, Huimin; Zhang, Feimin et al. (2018) Gold nanoparticles in injectable calcium phosphate cement enhance osteogenic differentiation of human dental pulp stem cells. Nanomedicine 14:35-45
Chen, Wenchuan; Liu, Xian; Chen, Qianmin et al. (2018) Angiogenic and osteogenic regeneration in rats via calcium phosphate scaffold and endothelial cell co-culture with human bone marrow mesenchymal stem cells (MSCs), human umbilical cord MSCs, human induced pluripotent stem cell-derived MSCs and human embry J Tissue Eng Regen Med 12:191-203
Xu, Hockin Hk; Wang, Ping; Wang, Lin et al. (2017) Calcium phosphate cements for bone engineering and their biological properties. Bone Res 5:17056
Qin, Wei; Huang, Qi-Ting; Weir, Michael D et al. (2017) Alcohol Inhibits Odontogenic Differentiation of Human Dental Pulp Cells by Activating mTOR Signaling. Stem Cells Int 2017:8717454
Liu, Xian; Chen, Wenchuan; Zhang, Chi et al. (2017) Co-Seeding Human Endothelial Cells with Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells on Calcium Phosphate Scaffold Enhances Osteogenesis and Vascularization in Rats. Tissue Eng Part A 23:546-555
Wang, Lin; Zhang, Chi; Li, Chunyan et al. (2016) Injectable calcium phosphate with hydrogel fibers encapsulating induced pluripotent, dental pulp and bone marrow stem cells for bone repair. Mater Sci Eng C Mater Biol Appl 69:1125-36
Wang, Ping; Song, Yang; Weir, Michael D et al. (2016) A self-setting iPSMSC-alginate-calcium phosphate paste for bone tissue engineering. Dent Mater 32:252-63
Wang, Lin; Wang, Ping; Weir, Michael D et al. (2016) Hydrogel fibers encapsulating human stem cells in an injectable calcium phosphate scaffold for bone tissue engineering. Biomed Mater 11:065008
Wang, Ping; Liu, Xian; Zhao, Liang et al. (2015) Bone tissue engineering via human induced pluripotent, umbilical cord and bone marrow mesenchymal stem cells in rat cranium. Acta Biomater 18:236-48

Showing the most recent 10 out of 93 publications