Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
2R01DK019952-19A1
Application #
2137415
Study Section
Metabolism Study Section (MET)
Project Start
1977-05-01
Project End
1999-06-30
Budget Start
1996-07-25
Budget End
1997-06-30
Support Year
19
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Virginia
Department
Pharmacology
Type
Schools of Medicine
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Bigler Wang, Dora; Sherman, Nicholas E; Shannon, John D et al. (2011) Binding of ?4?5 by adenosine A1 and A2A receptors determined by stable isotope labeling with amino acids in cell culture and mass spectrometry. Biochemistry 50:207-20
McIntire, William E (2009) Structural determinants involved in the formation and activation of G protein betagamma dimers. Neurosignals 17:82-99
Wu, Yang; Buranda, Tione; Simons, Peter C et al. (2007) Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Anal Biochem 371:10-20
Myung, Chang-Seon; Lim, William K; DeFilippo, Joseph M et al. (2006) Regions in the G protein gamma subunit important for interaction with receptors and effectors. Mol Pharmacol 69:877-87
Mayeenuddin, Linnia H; McIntire, William E; Garrison, James C (2006) Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers. J Biol Chem 281:1913-20
DePuy, Seth D; Yao, Junlan; Hu, Changlong et al. (2006) The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits. Proc Natl Acad Sci U S A 103:14590-5
McIntire, William E; MacCleery, Gavin; Murphree, Lauren J et al. (2006) Influence of differential stability of G protein betagamma dimers containing the gamma11 subunit on functional activity at the M1 muscarinic receptor, A1 adenosine receptor, and phospholipase C-beta. Biochemistry 45:11616-31
Mayeenuddin, Linnia H; Garrison, James C (2006) Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. J Biol Chem 281:1921-8
Kerchner, Kristi R; Clay, Robert L; McCleery, Gavin et al. (2004) Differential sensitivity of phosphatidylinositol 3-kinase p110gamma to isoforms of G protein betagamma dimers. J Biol Chem 279:44554-62
Lukov, Georgi L; Myung, Chang-Seon; McIntire, William E et al. (2004) Role of the isoprenyl pocket of the G protein beta gamma subunit complex in the binding of phosducin and phosducin-like protein. Biochemistry 43:5651-60

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