This proposal focuses on the actions of glucagon on the liver. It addresses three basic questions: 1) What are the initial changes in Na+, K+, H+ and Ca2+ ion fluxes following glucagon administration? What is the connection between the different ion movements? What is the mechanism of Ca2+ release? 2) A comparison between the effects of glucagon and vasopressin on Ca2+ efflux. 3) Studies aimed at localizing the step(s) in the gluconeogenic pathway which are influenced by a rise in cytosolic Ca2+. The experiments will be carried out using the in situ perfused rat liver and isolated hepatocytes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK036916-04
Application #
3235520
Study Section
Physical Biochemistry Study Section (PB)
Project Start
1986-12-01
Project End
1991-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Texas Health Science Center Houston
Department
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225
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