Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK038578-15
Application #
6607440
Study Section
Nutrition Study Section (NTN)
Program Officer
Laughlin, Maren R
Project Start
1987-07-01
Project End
2005-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
15
Fiscal Year
2003
Total Cost
$296,000
Indirect Cost
Name
University of Virginia
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Charlottesville
State
VA
Country
United States
Zip Code
22904
Keske, Michelle A; Clerk, Lucy H; Price, Wendie J et al. (2009) Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal. Diabetes Care 32:1672-7
Maier, Christina; Clodi, Martin; Neuhold, Stephanie et al. (2009) Endothelial markers may link kidney function to cardiovascular events in type 2 diabetes. Diabetes Care 32:1890-5
Clerk, Lucy H; Vincent, Michelle A; Barrett, Eugene J et al. (2007) Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. Am J Physiol Endocrinol Metab 293:E1804-9
Liu, Zhenqi; Long, Wen; Fryburg, David A et al. (2006) The regulation of body and skeletal muscle protein metabolism by hormones and amino acids. J Nutr 136:212S-7S
Wang, Hong; Liu, Zhenqi; Li, Guolian et al. (2006) The vascular endothelial cell mediates insulin transport into skeletal muscle. Am J Physiol Endocrinol Metab 291:E323-32
Clerk, Lucy H; Vincent, Michelle A; Jahn, Linda A et al. (2006) Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 55:1436-42
Vincent, Michelle A; Clerk, Lucy H; Lindner, Jonathan R et al. (2006) Mixed meal and light exercise each recruit muscle capillaries in healthy humans. Am J Physiol Endocrinol Metab 290:E1191-7
Vincent, Michelle A; Clerk, Lucy H; Rattigan, Stephen et al. (2005) Active role for the vasculature in the delivery of insulin to skeletal muscle. Clin Exp Pharmacol Physiol 32:302-7
Li, Guolian; Barrett, Eugene J; Wang, Hong et al. (2005) Insulin at physiological concentrations selectively activates insulin but not insulin-like growth factor I (IGF-I) or insulin/IGF-I hybrid receptors in endothelial cells. Endocrinology 146:4690-6
Vincent, Michelle A; Clerk, Lucy H; Lindner, Jonathan R et al. (2004) Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 53:1418-23

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