Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK041873-09
Application #
2141958
Study Section
Pathology B Study Section (PTHB)
Project Start
1989-08-15
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Alexander, Jessy J; Chaves, Lee D; Chang, Anthony et al. (2016) Abrogation of immune complex glomerulonephritis by native carboxypeptidase and pharmacological antagonism of the C5a receptor. Cell Mol Immunol 13:651-7
Alexander, Jessy J; Chaves, Lee D; Chang, Anthony et al. (2015) CD11b is protective in complement-mediated immune complex glomerulonephritis. Kidney Int 87:930-9
Chaves, Lee Daniel; Bao, Lihua; Wang, Ying et al. (2014) Loss of CD11b exacerbates murine complement-mediated tubulointerstitial nephritis. PLoS One 9:e92051
Cravedi, Paolo; van der Touw, William; Heeger, Peter S (2013) Complement regulation of T-cell alloimmunity. Semin Nephrol 33:565-74
Chaves, Lee D; Mathew, Liby; Shakaib, Mohammed et al. (2013) Contrasting effects of systemic monocyte/macrophage and CD4+ T cell depletion in a reversible ureteral obstruction mouse model of chronic kidney disease. Clin Dev Immunol 2013:836989
Naik, Abhijit; Sharma, Shweta; Quigg, Richard J (2013) Complement regulation in renal disease models. Semin Nephrol 33:575-85
Jacob, Alexander; Chaves, Lee; Eadon, Michael T et al. (2013) Curcumin alleviates immune-complex-mediated glomerulonephritis in factor-H-deficient mice. Immunology 139:328-37
Alexander, Jessy J; Chaves, Lee; Chang, Anthony et al. (2012) The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int 82:961-8
Bao, Lihua; Wang, Ying; Haas, Mark et al. (2011) Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury. Kidney Int 80:524-34
Bao, Lihua; Haas, Mark; Quigg, Richard J (2011) Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol 22:285-95

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