Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK044875-02S1
Application #
3246387
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1992-09-01
Project End
1995-08-31
Budget Start
1992-09-01
Budget End
1993-08-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
048682157
City
Seattle
State
WA
Country
United States
Zip Code
98105
Sweeney, W E; Chen, Y; Nakanishi, K et al. (2000) Treatment of polycystic kidney disease with a novel tyrosine kinase inhibitor. Kidney Int 57:33-40
Sweeney, W E; Futey, L; Frost, P et al. (1999) In vitro modulation of cyst formation by a novel tyrosine kinase inhibitor. Kidney Int 56:406-13
Sweeney Jr, W E; Avner, E D (1998) Functional activity of epidermal growth factor receptors in autosomal recessive polycystic kidney disease. Am J Physiol 275:F387-94
Yoder, B K; Richards, W G; Sommardahl, C et al. (1997) Differential rescue of the renal and hepatic disease in an autosomal recessive polycystic kidney disease mouse mutant. A new model to study the liver lesion. Am J Pathol 150:2231-41
Orellana, S A; Neff, C D; Sweeney, W E et al. (1996) Novel Madin Darby canine kidney cell clones exhibit unique phenotypes in response to morphogens. In Vitro Cell Dev Biol Anim 32:329-39
Yoder, B K; Richards, W G; Sommardahl, C et al. (1996) Functional correction of renal defects in a mouse model for ARPKD through expression of the cloned wild-type Tg737 cDNA. Kidney Int 50:1240-8
Orellana, S A; Sweeney, W E; Neff, C D et al. (1995) Epidermal growth factor receptor expression is abnormal in murine polycystic kidney. Kidney Int 47:490-9
Nauta, J; Sweeney, W E; Rutledge, J C et al. (1995) Biliary epithelial cells from mice with congenital polycystic kidney disease are hyperresponsive to epidermal growth factor. Pediatr Res 37:755-63
Yoder, B K; Richards, W G; Sweeney, W E et al. (1995) Insertional mutagenesis and molecular analysis of a new gene associated with polycystic kidney disease. Proc Assoc Am Physicians 107:314-23
Orellana, S A; Avner, E D (1995) Cystic maldevelopment of the kidney. Semin Nephrol 15:341-52

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