Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK046686-04
Application #
2145956
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-06-12
Budget End
1998-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Laing, James G; Saffitz, Jeffrey E; Steinberg, Thomas H et al. (2007) Diminished zonula occludens-1 expression in the failing human heart. Cardiovasc Pathol 16:159-64
Henriksen, Zanne; Hiken, Jeffrey F; Steinberg, Thomas H et al. (2006) The predominant mechanism of intercellular calcium wave propagation changes during long-term culture of human osteoblast-like cells. Cell Calcium 39:435-44
Laing, J G; Koval, M; Steinberg, T H (2005) Association with ZO-1 correlates with plasma membrane partitioning in truncated connexin45 mutants. J Membr Biol 207:45-53
Laing, James G; Chou, Brian C; Steinberg, Thomas H (2005) ZO-1 alters the plasma membrane localization and function of Cx43 in osteoblastic cells. J Cell Sci 118:2167-76
Lin, George C; Rurangirwa, Jacqueline K; Koval, Michael et al. (2004) Gap junctional communication modulates agonist-induced calcium oscillations in transfected HeLa cells. J Cell Sci 117:881-7
Hiken, Jeffrey F; Steinberg, Thomas H (2004) ATP downregulates P2X7 and inhibits osteoclast formation in RAW cells. Am J Physiol Cell Physiol 287:C403-12
Jorgensen, Niklas R; Henriksen, Zanne; Sorensen, Ole H et al. (2002) Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors. J Biol Chem 277:7574-80
Laing, J G; Manley-Markowski, R N; Koval, M et al. (2001) Connexin45 interacts with zonula occludens-1 and connexin43 in osteoblastic cells. J Biol Chem 276:23051-5
Lecanda, F; Warlow, P M; Sheikh, S et al. (2000) Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol 151:931-44
Jorgensen, N R; Henriksen, Z; Brot, C et al. (2000) Human osteoblastic cells propagate intercellular calcium signals by two different mechanisms. J Bone Miner Res 15:1024-32

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