Molecular Biology of Parathyroid & Renal CA++ Receptors

Brown, Edward M M.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK048330-03
• Application #: 2148547
• Study Section: General Medicine B Study Section (GMB)
• Project Start: 1994-07-11
• Project End: 1999-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: Brigham and Women's Hospital
• DUNS #: 071723621
• City: Boston
• State: MA
• Country: United States
• Zip Code: 02115

Publications

Bandyopadhyay, Sanghamitra; Jeong, Kyeong-Hoon; Hansen, Jacob Tfelt et al. (2007) Calcium-sensing receptor stimulates secretion of an interferon-gamma-induced monokine (CXCL10) and monocyte chemoattractant protein-3 in immortalized GnRH neurons. J Neurosci Res 85:882-95

Chattopadhyay, Naibedya; Jeong, Kyeong-Hoon; Yano, Shozo et al. (2007) Calcium receptor stimulates chemotaxis and secretion of MCP-1 in GnRH neurons in vitro: potential impact on reduced GnRH neuron population in CaR-null mice. Am J Physiol Endocrinol Metab 292:E523-32

Yano, Shozo; Mentaverri, Romuald; Kanuparthi, Deepthi et al. (2005) Functional expression of beta-chemokine receptors in osteoblasts: role of regulated upon activation, normal T cell expressed and secreted (RANTES) in osteoblasts and regulation of its secretion by osteoblasts and osteoclasts. Endocrinology 146:2324-35

Tfelt-Hansen, Jacob; Ferreira, Ana; Yano, Shozo et al. (2005) Calcium-sensing receptor activation induces nitric oxide production in H-500 Leydig cancer cells. Am J Physiol Endocrinol Metab 288:E1206-13

Mallya, Sanjay M; Gallagher, James J; Wild, Yvette K et al. (2005) Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism. Mol Endocrinol 19:2603-9

Tfelt-Hansen, Jacob; Yano, Shozo; John Macleod, R et al. (2005) High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors 23:117-23

Tfelt-Hansen, J; Chattopadhyay, N; Yano, S et al. (2004) Calcium-sensing receptor induces proliferation through p38 mitogen-activated protein kinase and phosphatidylinositol 3-kinase but not extracellularly regulated kinase in a model of humoral hypercalcemia of malignancy. Endocrinology 145:1211-7

Ye, Chian Ping; Yano, Shozo; Tfelt-Hansen, Jacob et al. (2004) Regulation of a Ca2+-activated K+ channel by calcium-sensing receptor involves p38 MAP kinase. J Neurosci Res 75:491-8

Kifor, Olga; McElduff, Aidan; LeBoff, Meryl S et al. (2004) Activating antibodies to the calcium-sensing receptor in two patients with autoimmune hypoparathyroidism. J Clin Endocrinol Metab 89:548-56

Chattopadhyay, Naibedya; T-Felt Hansen, Jacob; Godbole, Madan M et al. (2004) Transforming growth factor beta receptor family ligands inhibit hepatocyte growth factor synthesis and secretion from astrocytoma cells. Brain Res Mol Brain Res 121:146-50