The long-term goal is to elucidate the functions of hamartin and tuberin.
Specific Aims i nclude 1) to identify the germline """"""""first hit"""""""" and somatic """"""""second hit"""""""" mutations in TSC-associated renal cell carcinomas, 2) to identify other somatic genetic events involved in the development of renal cell carcinoma in TSC patients, 3) to define the hamartin-tuberin interaction domain and to determine the effects of naturally occurring mutations on the hamartin-tuberin interaction, and 4) to determine the role of hamartin in cell cycle regulation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
3R01DK051052-06S1
Application #
6446529
Study Section
Pathology B Study Section (PTHB)
Program Officer
Hirschman, Gladys H
Project Start
1995-09-30
Project End
2004-08-31
Budget Start
2000-09-01
Budget End
2001-08-31
Support Year
6
Fiscal Year
2001
Total Cost
$86,417
Indirect Cost
Name
Fox Chase Cancer Center
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19111
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