Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK060588-07
Application #
6517985
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Mullins, Christopher V
Project Start
2001-05-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
7
Fiscal Year
2002
Total Cost
$267,750
Indirect Cost
Name
Veterans Medical Research Fdn/San Diego
Department
Type
DUNS #
933863508
City
San Diego
State
CA
Country
United States
Zip Code
92161
Grzesiak, John J; Smith, Kathy C; Burton, Douglas W et al. (2007) Integrin-mediated laminin-1 adhesion upregulates CXCR4 and IL-8 expression in pancreatic cancer cells. Surgery 141:804-14
Pache, Jared C; Burton, Douglas W; Deftos, Leonard J et al. (2006) A carboxyl leucine-rich region of parathyroid hormone-related protein is critical for nuclear export. Endocrinology 147:990-8
Grzesiak, John J; Burton, Douglas W; Deftos, Leonard J et al. (2006) Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro. Peptides 27:1898-901
Grzesiak, John J; Smith, Kathy C; Burton, Douglas W et al. (2005) GSK3 and PKB/Akt are associated with integrin-mediated regulation of PTHrP, IL-6 and IL-8 expression in FG pancreatic cancer cells. Int J Cancer 114:522-30
Grzesiak, John J; Smith, Kathy C; Chalberg, Cheryl et al. (2005) Heat shock protein-70 expressed on the surface of cancer cells binds parathyroid hormone-related protein in vitro. Endocrinology 146:3567-76
Grzesiak, John J; Smith, Kathy C; Chalberg, Cheryl et al. (2005) Type I collagen and divalent cation shifts disrupt cell-cell adhesion, increase migration, and decrease PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells. Int J Gastrointest Cancer 36:131-46
Grzesiak, John J; Clopton, Paul; Chalberg, Cheryl et al. (2004) The extracellular matrix differentially regulates the expression of PTHrP and the PTH/PTHrP receptor in FG pancreatic cancer cells. Pancreas 29:85-92
Hastings, Randolph H; Quintana, Rick A; Sandoval, Rebeca et al. (2003) Amino-terminal and midmolecule parathyroid hormone-related protein, phosphatidylcholine, and type II cell proliferation in silica-injured lung. Am J Physiol Lung Cell Mol Physiol 285:L1312-22
Hastings, Randolph H; Araiza, Flavio; Burton, Douglas W et al. (2003) Parathyroid hormone-related protein ameliorates death receptor-mediated apoptosis in lung cancer cells. Am J Physiol Cell Physiol 285:C1429-36
Silverberg, Shonni J; Bilezikian, John P (2003) ""Incipient"" primary hyperparathyroidism: a ""forme fruste"" of an old disease. J Clin Endocrinol Metab 88:5348-52

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