Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK060732-02
Application #
6709379
Study Section
Endocrinology Study Section (END)
Program Officer
Blondel, Olivier
Project Start
2003-03-01
Project End
2006-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
2
Fiscal Year
2004
Total Cost
$311,850
Indirect Cost

  Institution

Name
University of Rochester
Department
Pathology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627

  Publications

Clementi, Alicia H; Gaudy, Allison M; Zimmers, Teresa A et al. (2011) Deletion of interleukin-6 improves pyruvate tolerance without altering hepatic insulin signaling in the leptin receptor-deficient mouse. Metabolism 60:1610-9
Gaudy, Allison M; Clementi, Alicia H; Campbell, Jean S et al. (2010) Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes. J Biol Chem 285:41356-65
Clementi, Alicia H; Gaudy, Allison M; van Rooijen, Nico et al. (2009) Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling. Biochim Biophys Acta 1792:1062-72
Mooney, Robert A (2007) Counterpoint: Interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J Appl Physiol 102:816-8;discussion 818-9
Klover, Peter J; Zimmers, Teresa A; Koniaris, Leonidas G et al. (2003) Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52:2784-9