Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK061761-02
Application #
6484057
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (02))
Program Officer
Serrano, Jose
Project Start
2000-12-01
Project End
2004-11-30
Budget Start
2001-06-01
Budget End
2001-11-30
Support Year
2
Fiscal Year
2001
Total Cost
$125,438
Indirect Cost

  Institution

Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

LaDu, Mary Jo; Stine Jr, W Blaine; Narita, Masaaki et al. (2006) Self-assembly of HEK cell-secreted ApoE particles resembles ApoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein. Biochemistry 45:381-90
Li, Yonghe; Chen, Jianglei; Lu, Wenyan et al. (2005) Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding. J Cell Sci 118:5305-14
McCormick, Lynn M; Urade, Reiko; Arakaki, Yukino et al. (2005) Independent and cooperative roles of N-glycans and molecular chaperones in the folding and disulfide bond formation of the low-density lipoprotein (LDL) receptor-related protein. Biochemistry 44:5794-803
Li, Yonghe; Lu, Wenyan; Schwartz, Alan L et al. (2004) Degradation of the LDL receptor class 2 mutants is mediated by a proteasome-dependent pathway. J Lipid Res 45:1084-91
Li, Yonghe; Lu, Wenyan; Bu, Guojun (2003) Essential role of the low density lipoprotein receptor-related protein in vascular smooth muscle cell migration. FEBS Lett 555:346-50
Melman, Lora; Geuze, Hans J; Li, Yonghe et al. (2002) Proteasome regulates the delivery of LDL receptor-related protein into the degradation pathway. Mol Biol Cell 13:3325-35