Abstract

Minimally-invasive catheter-based interventions have revolutionized our treatment of cardiovascular disease. X-ray techniques have been the established method for imaging coronary and vascular disease and guiding interventional therapeutic devices. X-ray, however, does not directly visualize the diseased atherosclerotic tissue, limiting more advanced vascular interventions. Magnetic resonance imaging (MRI), by comparison, provides excellent tissue contrast and can image both the vessel lumen and the vessel wall without relying on contrast agents. At Stanford we have been actively developing real-time interactive MR imaging systems for diagnostic cardiac imaging, and for the guidance of interventional procedures. In this proposal we will significantly extend this work to the visualization and control of devices for vascular interventions, and the integration of these capabilities into a multi-functional interactive real-time interface. The major focus will be to develop a fully integrated MRI system for real-time vascular interventions and to optimize its capabilities in animal models for the treatment of chronic total occlusions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB002992-02
Application #
6801986
Study Section
Special Emphasis Panel (ZRG1-SRB (53))
Program Officer
Haller, John W
Project Start
2003-09-19
Project End
2007-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
2
Fiscal Year
2004
Total Cost
$380,381
Indirect Cost

  Institution

Name
Stanford University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Lustig, Michael; Kim, Seung-Jean; Pauly, John M (2008) A fast method for designing time-optimal gradient waveforms for arbitrary k-space trajectories. IEEE Trans Med Imaging 27:866-73
Santos, Juan M; Cunningham, Charles H; Lustig, Michael et al. (2006) Single breath-hold whole-heart MRA using variable-density spirals at 3T. Magn Reson Med 55:371-9
Rieke, Viola; Ganguly, Arundhuti; Daniel, Bruce L et al. (2005) X-ray compatible radiofrequency coil for magnetic resonance imaging. Magn Reson Med 53:1409-14
Terashima, Masahiro; Hyon, MinSu; de la Pena-Almaguer, Erasmo et al. (2005) High-resolution real-time spiral MRI for guiding vascular interventions in a rabbit model at 1.5 T. J Magn Reson Imaging 22:687-90
Cunningham, Charles H; Arai, Takayasu; Yang, Phillip C et al. (2005) Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med 53:999-1005
Beatty, Philip J; Nishimura, Dwight G; Pauly, John M (2005) Rapid gridding reconstruction with a minimal oversampling ratio. IEEE Trans Med Imaging 24:799-808
Butts, Kim; Pauly, John M; Gold, Garry E (2005) Reduction of blurring in view angle tilting MRI. Magn Reson Med 53:418-24