Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES002521-14
Application #
2153137
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1982-01-01
Project End
1998-06-30
Budget Start
1996-04-01
Budget End
1997-06-30
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wayne State University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Detroit
State
MI
Country
United States
Zip Code
48202
Starcevic, S L; Elferink, C; Novak, R F (2001) Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease. J Natl Cancer Inst 93:776-82
Shen, K; Novak, R F (1997) DDT stimulates c-erbB2, c-met, and STATS tyrosine phosphorylation, Grb2-Sos association, MAPK phosphorylation, and proliferation of human breast epithelial cells. Biochem Biophys Res Commun 231:17-21
Shen, K; Novak, R F (1997) Fas-signaling and effects on receptor tyrosine kinase signal transduction in human breast epithelial cells. Biochem Biophys Res Commun 230:89-93
Gruebele, A; Zawaski, K; Kaplan, D et al. (1996) Cytochrome P4502E1- and cytochrome P4502B1/2B2-catalyzed carbon tetrachloride metabolism: effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-kappa B transcription factor leve Drug Metab Dispos 24:15-22
Zangar, R C; Reiners Jr, J J; Novak, R F (1995) Gender-specific and developmental differences in protein kinase C isozyme expression in rat liver. Carcinogenesis 16:2593-7
Runge-Morris, M; Wu, N; Novak, R F (1994) Hydrazine-mediated DNA damage: role of hemoprotein, electron transport, and organic free radicals. Toxicol Appl Pharmacol 125:123-32
Runge-Morris, M; Novak, R F (1993) Effects of phenelzine and hydralazine on hydrogen peroxide production and proteolysis in human red blood cells. J Pharmacol Exp Ther 267:1401-6
Zawaski, K; Gruebele, A; Kaplan, D et al. (1993) Evidence for enhanced expression of c-fos, c-jun, and the Ca(2+)-activated neutral protease in rat liver following carbon tetrachloride administration. Biochem Biophys Res Commun 197:585-90
Mortensen, A M; Novak, R F (1992) Dynamic changes in the distribution of the calcium-activated neutral protease in human red blood cells following cellular insult and altered Ca2+ homeostasis. Toxicol Appl Pharmacol 117:180-8
Mortensen, A M; Novak, R F (1991) Enhanced proteolysis and changes in membrane-associated calpain following phenylhydrazine insult to human red cells. Toxicol Appl Pharmacol 110:435-49

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