It is generally accepted that chemical control of insects at some level will be necessary for the preservation of human health and for agricultural productivity in the foreseeable future. If we are to meet these health and productivity standards while protecting the environment and man from potentially dangerous pesticides, we must a) develop safe, biodegradable pest control agents, b) understand xenobiotic metabolism in target and nontarget organisms, and c) develop rapid, sensitive analytical methods capable of detecting potentially dangerous xenobiotics. Thus, the long-term goal of this project is the safeguarding of human and environmental health by solving aspects of the above problems. I. We will develop new leads for environmentally acceptable insect control agents by investigating the critical events in the metamorphosis of our most destructive insect pests. THese leads can hopefully be exploited by both classical chemistry and genetic engineering. II. Since the epoxide moiety is the reactive center in some of the most dangerous toxins, mutagens and carcinogens known, we will investigate its metabolism in mammalian systems. Special attention will be paid to the induction and inhibition of these systems. Using selective substrates, inducers and inhibitors, we will work toward the development of a predictive model of epoxide catabolism. III. Finally, we will evaluate immunochemical technology as a technique capable of rapidly and inexpensively analyzing both classical and innovative pesticides.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES002710-10
Application #
3250023
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1980-12-01
Project End
1992-11-30
Budget Start
1989-12-01
Budget End
1990-11-30
Support Year
10
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of California Davis
Department
Type
Schools of Earth Sciences/Natur
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618
Guedes, A G P; Aristizabal, F; Sole, A et al. (2018) Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J Vet Pharmacol Ther 41:230-238
?ertíková Chábová, V?ra; Kujal, Petr; Škaroupková, Petra et al. (2018) Combined Inhibition of Soluble Epoxide Hydrolase and Renin-Angiotensin System Exhibits Superior Renoprotection to Renin-Angiotensin System Blockade in 5/6 Nephrectomized Ren-2 Transgenic Hypertensive Rats with Established Chronic Kidney Disease. Kidney Blood Press Res 43:329-349
Kodani, Sean D; Bhakta, Saavan; Hwang, Sung Hee et al. (2018) Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase. Bioorg Med Chem Lett 28:762-768
Rand, Amy A; Helmer, Patrick O; Inceoglu, Bora et al. (2018) LC-MS/MS Analysis of the Epoxides and Diols Derived from the Endocannabinoid Arachidonoyl Ethanolamide. Methods Mol Biol 1730:123-133
Swardfager, W; Hennebelle, M; Yu, D et al. (2018) Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target. Neurosci Biobehav Rev 87:56-66
Burmistrov, Vladimir; Morisseau, Christophe; Harris, Todd R et al. (2018) Effects of adamantane alterations on soluble epoxide hydrolase inhibition potency, physical properties and metabolic stability. Bioorg Chem 76:510-527
Wang, Weicang; Yang, Jun; Zhang, Jianan et al. (2018) Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation. Proc Natl Acad Sci U S A 115:5283-5288
Burmistrov, Vladimir; Morisseau, Christophe; Pitushkin, Dmitry et al. (2018) Adamantyl thioureas as soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett 28:2302-2313
Tu, Ranran; Armstrong, Jillian; Lee, Kin Sing Stephen et al. (2018) Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep 8:5279
Taha, Ameer Y; Hennebelle, Marie; Yang, Jun et al. (2018) Regulation of rat plasma and cerebral cortex oxylipin concentrations with increasing levels of dietary linoleic acid. Prostaglandins Leukot Essent Fatty Acids 138:71-80

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