Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES003832-02
Application #
3251562
Study Section
Chemical Pathology Study Section (CPA)
Project Start
1985-12-06
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
2
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Nebraska Medical Center
Department
Type
Overall Medical
DUNS #
City
Omaha
State
NE
Country
United States
Zip Code
68198
Poch, Mark T; Al-Kassim, Loola; Smolinski, Steven M et al. (2004) Two distinct classes of CCAAT box elements that bind nuclear factor-Y/alpha-actinin-4: potential role in human CYP1A1 regulation. Toxicol Appl Pharmacol 199:239-50
Linder, M W; Falkner, K C; Srinivasan, G et al. (1999) Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor. Drug Metab Rev 31:247-71
Piechocki, M P; Hines, R N (1998) Functional characterization of the human CYP1A1 negative regulatory element: modulation of Ah receptor mediated transcriptional activity. Carcinogenesis 19:771-80
Boucher, P D; Piechocki, M P; Hines, R N (1995) Partial characterization of the human CYP1A1 negatively acting transcription factor and mutational analysis of its cognate DNA recognition sequence. Mol Cell Biol 15:5144-51
Boucher, P D; Hines, R N (1995) In vitro binding and functional studies comparing the human CYP1A1 negative regulatory element with the orthologous sequences from rodent genes. Carcinogenesis 16:383-92
Piechocki, M P; Hines, R N (1994) Oligonucleotide design and optimized protocol for site-directed mutagenesis. Biotechniques 16:702-7
Thomsen, J S; Wang, X; Hines, R N et al. (1994) Restoration of aryl hydrocarbon (Ah) responsiveness in MDA-MB-231 human breast cancer cells by transient expression of the estrogen receptor. Carcinogenesis 15:933-7
Boucher, P D; Ruch, R J; Hines, R N (1993) Specific nuclear protein binding to a negative regulatory element on the human CYP1A1 gene. J Biol Chem 268:17384-91
Thomsen, J S; Nissen, L; Stacey, S N et al. (1991) Differences in 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible CYP1A1 expression in human breast carcinoma cell lines involve altered trans-acting factors. Eur J Biochem 197:577-82
Hines, R N; Mathis, J M; Jacob, C S (1988) Identification of multiple regulatory elements on the human cytochrome P450IA1 gene. Carcinogenesis 9:1599-605

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