Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004140-06S1
Application #
3252110
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1991-08-07
Project End
1994-05-31
Budget Start
1991-08-07
Budget End
1992-05-31
Support Year
6
Fiscal Year
1991
Total Cost
Indirect Cost

  Institution

Name
Purdue University
Department
Type
Schools of Pharmacy
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907

  Publications

Leavesley, Heather B; Li, Li; Mukhopadhyay, Soma et al. (2010) Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons. Toxicol Sci 115:569-76
Zhang, Lu; Li, Li; Liu, Han et al. (2009) BNIP3 mediates cell death by different pathways following localization to endoplasmic reticulum and mitochondrion. FASEB J 23:3405-14
Zhang, X; Li, L; Zhang, L et al. (2009) Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression. Toxicol Appl Pharmacol 238:11-9
Leavesley, Heather B; Li, Li; Prabhakaran, Krishnan et al. (2008) Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity. Toxicol Sci 101:101-11
Li, L; Prabhakaran, K; Zhang, X et al. (2008) 1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation. J Neurosci Res 86:1397-408
Prabhakaran, K; Li, L; Zhang, L et al. (2007) Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells. Neuroscience 150:159-67
Zhang, X; Li, L; Prabhakaran, K et al. (2007) Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress. Toxicol Appl Pharmacol 223:10-9
Zhang, L; Li, L; Liu, H et al. (2007) HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death. Free Radic Biol Med 43:117-27
Prabhakaran, K; Li, L; Borowitz, J L et al. (2006) Inducible nitric oxide synthase up-regulation and mitochondrial glutathione depletion mediate cyanide-induced necrosis in mesencephalic cells. J Neurosci Res 84:1003-11
Li, Li; Prabhakaran, Krishnan; Zhang, Xun et al. (2006) PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells. Toxicol Sci 93:136-45

Showing the most recent 10 out of 65 publications