Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
3R01ES004628-01S1
Application #
3252729
Study Section
Toxicology Study Section (TOX)
Project Start
1988-03-01
Project End
1993-02-28
Budget Start
1988-03-01
Budget End
1989-02-28
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Schuetz, E G; Yasuda, K; Arimori, K et al. (1998) Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene. Arch Biochem Biophys 350:340-7
Furuya, K N; Bradley, G; Sun, D et al. (1997) Identification of a new P-glycoprotein-like ATP-binding cassette transporter gene that is overexpressed during hepatocarcinogenesis. Cancer Res 57:3708-16
Thottassery, J V; Zambetti, G P; Arimori, K et al. (1997) p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc Natl Acad Sci U S A 94:11037-42
Schuetz, E G; Schinkel, A H; Relling, M V et al. (1996) P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci U S A 93:4001-5
Strom, S C; Pisarov, L A; Dorko, K et al. (1996) Use of human hepatocytes to study P450 gene induction. Methods Enzymol 272:388-401
Schuetz, J D; Schuetz, E G; Thottassery, J V et al. (1996) Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol 49:63-72
Schuetz, E G; Beck, W T; Schuetz, J D (1996) Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 49:311-8
Schuetz, E G; Furuya, K N; Schuetz, J D (1995) Interindividual variation in expression of P-glycoprotein in normal human liver and secondary hepatic neoplasms. J Pharmacol Exp Ther 275:1011-8
Kocarek, T A; Schuetz, E G; Strom, S C et al. (1995) Comparative analysis of cytochrome P4503A induction in primary cultures of rat, rabbit, and human hepatocytes. Drug Metab Dispos 23:415-21
Kocarek, T A; Schuetz, E G; Guzelian, P S (1994) Regulation of cytochrome P450 2B1/2 mRNAs by Kepone (chlordecone) and potent estrogens in primary cultures of adult rat hepatocytes on Matrigel. Toxicol Lett 71:183-96

Showing the most recent 10 out of 24 publications