Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES005823-11
Application #
6621785
Study Section
Alcohol and Toxicology Subcommittee 4 (ALTX)
Program Officer
Weis, Brenda K
Project Start
2002-04-01
Project End
2007-03-31
Budget Start
2003-04-01
Budget End
2004-03-31
Support Year
11
Fiscal Year
2003
Total Cost
$298,000
Indirect Cost
Name
Wayne State University
Department
Type
Organized Research Units
DUNS #
001962224
City
Detroit
State
MI
Country
United States
Zip Code
48202
Barrett, Kathleen G; Fang, Hailin; Cukovic, Daniela et al. (2015) Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation. Drug Metab Dispos 43:1061-70
Rondini, Elizabeth A; Fang, Hailin; Runge-Morris, Melissa et al. (2014) Regulation of human cytosolic sulfotransferases 1C2 and 1C3 by nuclear signaling pathways in LS180 colorectal adenocarcinoma cells. Drug Metab Dispos 42:361-8
Duniec-Dmuchowski, Zofia; Rondini, Elizabeth A; Tibbs, Zachary E et al. (2014) Expression of the orphan cytosolic sulfotransferase SULT1C3 in human intestine: characterization of the transcript variant and implications for function. Drug Metab Dispos 42:352-60
Barrett, Kathleen G; Fang, Hailin; Gargano, Mary D et al. (2013) Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency. Drug Metab Dispos 41:1505-13
Runge-Morris, Melissa; Kocarek, Thomas A; Falany, Charles N (2013) Regulation of the cytosolic sulfotransferases by nuclear receptors. Drug Metab Rev 45:15-33
Salman, Emily D; He, Dongning; Runge-Morris, Melissa et al. (2011) Site-directed mutagenesis of human cytosolic sulfotransferase (SULT) 2B1b to phospho-mimetic Ser348Asp results in an isoform with increased catalytic activity. J Steroid Biochem Mol Biol 127:315-23
Fu, Jiaqi; Fang, Hailin; Paulsen, Michelle et al. (2011) Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells: role of the aryl hydrocarbon receptor. J Pharmacol Exp Ther 339:597-606
Bai, Qianming; Xu, Leyuan; Kakiyama, Genta et al. (2011) Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. Atherosclerosis 214:350-6
Fu, Jiaqi; Weise, Amy M; Falany, Josie L et al. (2010) Expression of estrogenicity genes in a lineage cell culture model of human breast cancer progression. Breast Cancer Res Treat 120:35-45
Cook, Ian T; Duniec-Dmuchowski, Zofia; Kocarek, Thomas A et al. (2009) 24-hydroxycholesterol sulfation by human cytosolic sulfotransferases: formation of monosulfates and disulfates, molecular modeling, sulfatase sensitivity, and inhibition of liver x receptor activation. Drug Metab Dispos 37:2069-78

Showing the most recent 10 out of 11 publications